ArticleNature protocols2013
Large-area molecular patterning with polymer pen lithography.
Article in Nature protocols, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- High-entropy 1D halide perovskite piezoelectrics found by megalibrary synthesis and rapid nonlinear optical screening.Science advances · 2026Article
- Polyelemental Nanoparticle Synthesis Enabled by Noncontact Metallothermic Reactions.Journal of the American Chemical Society · 2025Article
- Engineering multifunctional surface topography to regulate multiple biological responses.Biomaterials · 2025Review
- Soft lithography-based biomolecule patterning techniques and their applications in subcellular protein interaction analysis.Materials today. Bio · 2025Review
- Traversing the Periodic Table through Phase-Separating Nanoreactors.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Advancements in Lithography Techniques and Emerging Molecular Strategies for Nanostructure Fabrication.International journal of molecular sciences · 2025Review
- Creating chromaticity palettes and identifying white light emitters through nanocrystal megalibraries.Science advances · 2025Article
- Control of polymers' amorphous-crystalline transition enables miniaturization and multifunctional integration for hydrogel bioelectronics.Nature communications · 2024Article
- Localized Photoactuation of Polymer Pens for Nanolithography.Molecules (Basel, Switzerland) · 2023Article
- Photomechanochemical control over stereoselectivity in the [2 + 2] photodimerization of acenaphthylene.Faraday discussions · 2023Article
- Article
- Controlling Intracellular Machinery via Polymer Pen Lithography Molecular Patterning.ACS central science · 2022Article
- Binary-state scanning probe microscopy for parallel imaging.Nature communications · 2022Article
- Custom-made holey grapheneNanoscale advances · 2022Article
- Massively parallel cantilever-free atomic force microscopy.Nature communications · 2021Article
- Halide perovskite nanocrystal arrays: Multiplexed synthesis and size-dependent emission.Science advances · 2020Article
- Subcellular Control over Focal Adhesion Anisotropy, Independent of Cell Morphology, Dictates Stem Cell Fate.ACS nano · 2019Article
- Do-It-Yourself Pyramidal Mold for Nanotechnology.ACS omega · 2019Article
- Writing Behavior of Phospholipids in Polymer Pen Lithography (PPL) for Bioactive Micropatterns.Polymers · 2019Article
- Catalyst discovery through megalibraries of nanomaterials.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The challenge of constructing surfaces with nanostructured chemical functionality is central to many areas of biology and biotechnology. This protocol describes the steps required for performing molecular printing using polymer pen lithography (PPL), a cantilever-free scanning probe-based technique that can generate sub-100-nm molecular features in a massively parallel fashion. To illustrate how such molecular printing can be used for a variety of biologically relevant applications, we detail the fabrication of the lithographic apparatus and the deposition of two materials, an alkanethiol and a polymer onto a gold and silicon surface, respectively, and show how the present approach can be used to generate nanostructures composed of proteins and metals. Finally, we describe how PPL enables researchers to easily create combinatorial arrays of nanostructures, a powerful approach for high-throughput screening. A typical protocol for fabricating PPL arrays and printing with the arrays takes 48-72 h to complete, including two overnight waiting steps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.