Evidence map›Paper›PMID 24263062›Full record

SynthesisBritish journal of cancer2014

Association of sedentary behaviour with colon and rectal cancer: a meta-analysis of observational studies.

Y J Cong, Y Gan, H L Sun, J Deng, S Y Cao, X Xu, Z X Lu

Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05419531 (Measuring the Incidence of Colorectal Cancer in Young Endurance Athletes), which is not on this map. Cited by 44 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 5 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05419531 completednot on this mapstarted 2022, after this paper: background citation

Measuring the Incidence of Colorectal Cancer in Young Endurance Athletes

TypeobservationalSponsorInova Health Care ServicesRan2022 to 2025Enrolled94ConditionsColorectal CancerArmsprospective observational study - screening and follow up colonoscopy
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 5 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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  12. Deciphering the impact of dietary habits and behavioral patterns on colorectal cancer.International journal of surgery (London, England) · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Y J CongSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Y GanSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
H L SunSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
J DengSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
S Y CaoSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
X Xu1] School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China [2] Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Z X LuSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Huazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSedentary behaviour is ubiquitous in modern society. Emerging studies have focused on the health consequences of sedentary behaviour, including colorectal cancer, but whether sedentary behaviour is associated with the risks of colon and rectal cancer remains unclear. No systematic reviews have applied quantitative techniques to independently compute summary risk estimates. We aimed to conduct a meta-analysis to investigate this issue.

methodsWe searched PubMed, Embase, and Google Scholar databases up to May 2013 to identify cohort and case-control studies that evaluated the association between sedentary behaviour and colon or rectal cancer. A random-effect model was used to pool the results of included studies. Publication bias was assessed by using Begg's funnel plot.

resultsTwenty-three studies with 63 reports were included in our meta-analysis. These groups included 4,324,462 participants (27,231 colon cancer cases and 13,813 rectal cancer cases). Sedentary behaviour was significantly associated with colon cancer (relative risk (RR): 1.30, 95% confidence interval (CI): 1.22-1.39) but did not have a statistically significant association with rectal cancer (RR 1.05, 95% CI, 0.98-1.13). Subgroup analyses suggested that the odds ratio (OR) of colon cancer was 1.46 (95% CI: 1.22-1.68) in the case-control studies, and the RR was 1.27 (95% CI: 1.18-1.36) in the cohort studies, the OR of rectal cancer was 1.06 (95% CI: 0.85-1.33) in the case-control studies, and the RR was 1.06 (95% CI, 1.01-1.12) in the cohort studies.

conclusionSedentary behaviour is associated with an increased risk of colon cancer. Subgroup analyses suggest a positive association between sedentary behaviour and risk of rectal cancer in cohort studies. Reducing sedentary behaviour is potentially important for the prevention of colorectal cancer.

Indexed as

PubMedSedentary BehaviorAdultCase-Control StudiesCohort StudiesColonic NeoplasmsHumansRectal NeoplasmsRisk Factors

Identifiers

PMID24263062
PMCPMC3915109
OpenAlexW2080100095

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.