ArticleDevelopmental biology2014
Evolution of a developmental mechanism: Species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
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- TGF-β Signaling in Cranial Neural Crest Affects Late-Stage Mandibular Bone Resorption and Length.bioRxiv : the preprint server for biology · 2024Article
- A novel qPCR-based technique for identifying avian sex: An illustration within embryonic craniofacial bone.Genesis (New York, N.Y. : 2000) · 2024Article
- TGF-β signaling in the cranial neural crest affects late-stage mandibular bone resorption and length.Frontiers in physiology · 2024Article
- Neural crest cells as a source of microevolutionary variation.Seminars in cell & developmental biology · 2023Review
- Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Article
- Marsupials and Multi-Omics: Establishing New Comparative Models of Neural Crest Patterning and Craniofacial Development.Frontiers in cell and developmental biology · 2022Article
- Making and shaping endochondral and intramembranous bones.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Ciliopathic micrognathia is caused by aberrant skeletal differentiation and remodeling.Development (Cambridge, England) · 2021Article
- Ontogenetic origins of cranial convergence between the extinct marsupial thylacine and placental gray wolf.Communications biology · 2021Article
- Exceptional Changes in Skeletal Anatomy under Domestication: The Case of Brachycephaly.Integrative organismal biology (Oxford, England) · 2021Article
- Evolution and expansion of the RUNX2 QA repeat corresponds with the emergence of vertebrate complexity.Communications biology · 2020Review
- Neural crest lineage analysis: from past to future trajectory.Development (Cambridge, England) · 2020Review
- Stable integration of an optimized inducible promoter system enables spatiotemporal control of gene expression throughout avian development.Biology open · 2020Article
- Closing the gap from transcription to the structural connectome enhances the study of connections in the human brain.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Growth trajectories of prenatal embryos of the deep-sea shark Chlamydoselachus anguineus (Chondrichthyes).Journal of fish biology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Neural crest mesenchyme (NCM) controls species-specific pattern in the craniofacial skeleton but how this cell population accomplishes such a complex task remains unclear. To elucidate mechanisms through which NCM directs skeletal development and evolution, we made chimeras from quail and duck embryos, which differ markedly in their craniofacial morphology and maturation rates. We show that quail NCM, when transplanted into duck, maintains its faster timetable for development and autonomously executes molecular and cellular programs for the induction, differentiation, and mineralization of bone, including premature expression of osteogenic genes such as Runx2 and Col1a1. In contrast, the duck host systemic environment appears to be relatively permissive and supports osteogenesis independently by providing circulating minerals and a vascular network. Further experiments reveal that NCM establishes the timing of osteogenesis by regulating cell cycle progression in a stage- and species-specific manner. Altering the time-course of D-type cyclin expression mimics chimeras by accelerating expression of Runx2 and Col1a1. We also discover higher endogenous expression of Runx2 in quail coincident with their smaller craniofacial skeletons, and by prematurely over-expressing Runx2 in chick embryos we reduce the overall size of the craniofacial skeleton. Thus, our work indicates that NCM establishes species-specific size in the craniofacial skeleton by controlling cell cycle, Runx2 expression, and the timing of key events during osteogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.