ArticleThe Journal of cell biology1986
Cytokeratin No. 9, an epidermal type I keratin characteristic of a special program of keratinocyte differentiation displaying body site specificity.
Article in The Journal of cell biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 121 citations in OpenAlex.
- The "Swing-Door" Regrafting of Donor Site: An Alternative Method for Split-Thickness Skin Graft in the Hand.Archives of plastic surgery · 2024Article
- Differential cell composition and split epidermal differentiation in human palm, sole, and hip skin.Cell reports · 2023Article
- The case for considering volar skin in a "separate status" for wound healing.Frontiers in medicine · 2023Review
- Article
- A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus.Frontiers in cell and developmental biology · 2021Review
- dsRNA Sensing Induces Loss of Cell Identity.The Journal of investigative dermatology · 2019Article
- Impact of human mesenchymal cells of different body site origins on the maturation of dermo-epidermal skin substitutes.Pediatric surgery international · 2019Article
- Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis.Histochemistry and cell biology · 2019Article
- Corneocyte proteomics: Applications to skin biology and dermatology.Experimental dermatology · 2018Review
- The expression pattern of keratin 24 in tissue-engineered dermo-epidermal human skin substitutes in an in vivo model.Pediatric surgery international · 2018Article
- Anatomical and histological study to determine the border of sole skin.Surgical and radiologic anatomy : SRA · 2016Article
- The influence of stromal cells on the pigmentation of tissue-engineered dermo-epidermal skin grafts.Tissue engineering. Part A · 2015Article
- Keratin 9 is required for the structural integrity and terminal differentiation of the palmoplantar epidermis.The Journal of investigative dermatology · 2014Article
- Lipid droplets, perilipins and cytokeratins--unravelled liaisons in epithelium-derived cells.PloS one · 2013Article
- Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1).The journal of investigative dermatology. Symposium proceedings · 2009Review
- Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation.The Journal of cell biology · 2004Article
- Morphology of the keratin filament network in palm and sole skin: evidence for site-dependent features based on stereological analysis.Archives of dermatological research · 1996Article
- Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16.The Journal of cell biology · 1996Article
- Keratin 9 gene mutational heterogeneity in patients with epidermolytic palmoplantar keratoderma.Human genetics · 1994Article
- UNME/K1: an IgG2a monoclonal antibody specific to cytokeratin of human urinary bladder squamous cell carcinoma.Urological research · 1991Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plantar epidermis of the bovine heel pad as well as human plantar and palmar epidermis contain large amounts of an acidic (type I) keratin polypeptide (No. 9) of Mr 64,000 which so far has not been found in epidermis of other sites of the body. We present evidence for the keratinous nature of this protein, including its ability to form cytokeratin complexes and intermediate-sized filaments in vitro. We have isolated RNA from plantar epidermis of both species and show, using translation in vitro, that these polypeptides are genuine products of distinct mRNAs. Using immunofluorescence microscopy with specific antibodies against this protein, we demonstrate its location in most cells of suprabasal layers of plantar epidermis as well as in sparse keratinocytes which occur, individually or in small clusters, in upper layers of epidermis of other body locations. We conclude that cytokeratin No. 9 is characteristic of a special program of keratinocyte differentiation which during morphogenesis is expressed in most epidermal keratinocytes of soles and palms but only in a few keratinocytes at other body sites. This example of cell type-specific expression of a member of a multigene family in relation to a body site-related program of tissue differentiation raises important biological questions concerning the regulation of keratinocyte differentiation and morphogenesis as well as the function of such topological heterogeneity within a given type of tissue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.