Evidence map›Paper›PMID 24262783›Full record

ArticleEpilepsy & behavior : E&B2014

Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder.

Eduardo Pineda, J David Jentsch, Don Shin, Grace Griesbach, Raman Sankar, Andrey Mazarati

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior : E&B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 52 citations in OpenAlex.

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  12. Protective Role of L-3-Frontiers in pharmacology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Eduardo PinedaDepartment of Pediatrics, David Geffen School of Medicine at UCLA, USA.
J David JentschDepartment of Psychology, David Geffen School of Medicine at UCLA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, USA.
Don ShinDepartment of Pediatrics, David Geffen School of Medicine at UCLA, USA.
Grace GriesbachDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, USA.
Raman SankarDepartment of Pediatrics, David Geffen School of Medicine at UCLA, USA; Department of Neurology, David Geffen School of Medicine at UCLA, USA; UCLA Children's Discovery and Innovation Institute, USA.
Andrey MazaratiDepartment of Pediatrics, David Geffen School of Medicine at UCLA, USA; UCLA Children's Discovery and Innovation Institute, USA. Electronic address: mazarati@ucla.edu.
University of California, Los Angeles · US

Funding

Mechanisms of comorbidity between epilepsy and depressionR01NS065783 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAZARATI, ANDREY M · 2010 to 2017
$2.9M
The role of traumatic brain injury stress response on exercise therapyR01NS061960 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRIESBACH, GRACE S. · 2008 to 2012
$1.8M
Genetic Influences on Inhibitory Control and Cocaine SensitivityR01DA031852 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENTSCH, J. DAVID · 2012 to 2016
$1.7M
NIDA NIH HHS R01 DA031852NIDA NIH HHS R01DA031852NINDS NIH HHS R01 NS061960NINDS NIH HHS R01NS061960NINDS NIH HHS R01 NS065783NINDS NIH HHS R01NS065783
6 · The paper itself

Abstract

Attention deficit/hyperactivity disorder (ADHD) is encountered among patients with epilepsy at a significantly higher rate than in the general population. Mechanisms of epilepsy-ADHD comorbidity remain largely unknown. We investigated whether a model of chronic epilepsy in rats produces signs of ADHD, and thus, whether it can be used for studying mechanisms of this comorbidity. Epilepsy was induced in male Wistar rats via pilocarpine status epilepticus. Half of the animals exhibited chronic ADHD-like abnormalities, particularly increased impulsivity and diminished attention in the lateralized reaction-time task. These impairments correlated with the suppressed noradrenergic transmission in locus coeruleus outputs. The other half of animals exhibited depressive behavior in the forced swimming test congruently with the diminished serotonergic transmission in raphe nucleus outputs. Attention deficit/hyperactivity disorder and depressive behavior appeared mutually exclusive. Therefore, the pilocarpine model of epilepsy affords a system for reproducing and studying mechanisms of comorbidity between epilepsy and both ADHD and/or depression.

Indexed as

AnimalsAttention Deficit Disorder with HyperactivityBehavioral SymptomsBrainChronic DiseaseCompulsive BehaviorConvulsantsDisease Models, AnimalEpilepsyFunctional LateralityImmobility Response, TonicLithium ChlorideMalePhotic StimulationPilocarpineRatsConvulsantsLithium ChloridePilocarpine5-HTADHDattention deficit/hyperactivity disorderAttention deficit/hyperactivity disorderDepressionelevated plus maze testEpilepsyEPMTfast cyclic voltammetryFCVforced swimming testFSTlateralized reaction-time taskLateralized reaction-time taskLClocus coeruleusLRTTNEnorepinephrineNorepinephrinePFCprefrontal cortexraphe nucleusRNSEserotoninSerotoninstatus epilepticustemporal lobe epilepsyTLE

Identifiers

PMID24262783
PMCPMC3946735
OpenAlexW2041555129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.