ArticleAmerican journal of ophthalmology2014
Clinical manifestations of patients with intraocular inflammation and positive QuantiFERON-TB gold in-tube test in a country nonendemic for tuberculosis.
Article in American journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- A systemic review of the utility of antituberculosis therapy for presumed tuberculous uveitis.BMC infectious diseases · 2025Pooled it
- Anti-tubercular therapy for intraocular tuberculosis: A systematic review and meta-analysis.Survey of ophthalmologyPooled it
- A serum B-lymphocyte activation signature is a key distinguishing feature of the immune response in sarcoidosis compared to tuberculosis.Communications biology · 2024Article
- Treatment in Latent Tuberculosis Uveitis-Is Immunosuppression Effective or Is Conventional 3- or 4-Drug Antituberculosis Therapy Mandatory?Journal of clinical medicine · 2022Article
- Clinical Manifestations and Outcomes of Tubercular Uveitis in Taiwan-A Ten-Year Multicenter Retrospective Study.Medicina (Kaunas, Lithuania) · 2022Article
- Interferon-gamma release assays in tuberculous uveitis: a comprehensive review.International journal of ophthalmology · 2022Review
- The Association between QuantiFERON-TB Gold Test and Clinical Manifestations of Uveitis in the United States.American journal of ophthalmology · 2021Article
- Classification Criteria for Tubercular Uveitis.American journal of ophthalmology · 2021Article
- Classification Criteria for Sarcoidosis-Associated Uveitis.American journal of ophthalmology · 2021Article
- Immune Privilege: The Microbiome and Uveitis.Frontiers in immunology · 2020Review
- Clinical and Epidemiological Study on Tubercular Uveitis in a Tertiary Eye Care Centre in Italy.Journal of ophthalmology · 2020Article
- Paradoxical reactions in ocular tuberculosis.Journal of ophthalmic inflammation and infection · 2019Review
- Presumed tuberculous uveitis in a university-based tertiary referral center in Saudi Arabia.International ophthalmology · 2019Article
- The efficacy of latent tuberculosis treatment for immunocompetent uveitis patients with a positive T-SPOT.TB test: 6-year experience in a tuberculosis endemic region.International ophthalmology · 2018Article
- Review of people with retinal vasculitis and positive QuantiFERONInternational ophthalmology · 2018Article
- Early treatment of tuberculous uveitis improves visual outcome: a 10-year cohort study.Infection · 2018Article
- Tuberculosis and other causes of uveitis in Indonesia.Eye (London, England) · 2018Article
- Article
- What does IGRA testing add to the diagnosis of ocular tuberculosis? A Bayesian latent class analysis.BMC ophthalmology · 2017Article
- Tuberculous uveitis: association between anti-tuberculous therapy and clinical response in a non-endemic country.Journal of ophthalmic inflammation and infection · 2017Article
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7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate clinical manifestations of patients with uveitis and scleritis of unknown origin and positive QuantiFERON-TB Gold In-Tube test (quantiferon) in a country not endemic for tuberculosis.
designMulticenter retrospective cohort study.
methodsRetrospective review of the clinical, laboratory, and imaging data of 77 patients. Main outcome measures consisted of ocular and systemic features as well as results of laboratory examinations.
resultsOut of all, 60 of 71 (85%) were living for at least 6 months in tuberculosis-endemic regions. Location of uveitis was variable; posterior uveitis (29/77; 38%) was the most frequent. Two clinical entities were commonly noted: retinal occlusive vasculitis (21/77; 27%) and serpiginoid choroiditis (11/77; 14%). Antituberculosis treatment was completed in 32 patients; 29 of them (91%) achieved complete remission. Mean quantiferon level was 7.5 U/mL; 71% had values above 2 U/mL and 41% above 10 U/mL. We observed no associations between quantiferon levels and clinical and/or imaging features. Previous tuberculosis infection was diagnosed in 5 of 77 patients (6.5%), while hilar/mediastinal lymphadenopathy was found in 25 of 76 patients (33%). Of these, 12 were consistent with the diagnosis of sarcoidosis, 9 were typical for (prior) tuberculosis, and 4 were compatible with both diagnoses.
conclusionsOcular features of patients with idiopathic uveitis and positive quantiferon were diverse, but retinal occlusive vasculitis and serpiginoid choroiditis were common. The quantiferon levels were usually highly elevated and 33% of patients exhibited lymphadenopathy, suggesting frequently the diagnosis of sarcoidosis. Ocular inflammation reacted favorably to antituberculosis treatment, although only a small minority had documented (prior) tuberculosis.
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