Evidence map›Paper›PMID 24262390›Full record

ReviewJournal of molecular biology2014

Recognition of herpes simplex viruses: toll-like receptors and beyond.

Yijie Ma, Bin He

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 108 citations in OpenAlex.

  1. Trial
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  3. Nociceptor neurons shape antiviral immunity.Journal of neuroinflammation · 2026
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yijie MaDepartment of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA.
Bin HeDepartment of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA. Electronic address: tshuo@uic.edu.
University of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · US

Funding

HSV encoded viral functionsR21AI092230 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HE, BIN · 2011 to 2012
$420k
NIAID NIH HHS AI092230NIAID NIH HHS R21 AI092230
6 · The paper itself

Abstract

Herpes simplex viruses (HSVs) are human pathogens that establish lytic and latent infections. Reactivation from latency occurs intermittently, which represents a lifelong source of recurrent infection. In this complex process, HSV triggers and neutralizes innate immunity. Therefore, a dynamic equilibrium between HSV and the innate immune system determines the outcome of viral infection. Detection of HSV involves pathogen recognition receptors that include Toll-like receptors, retinoic acid-inducible gene I-like receptors, and cytosolic DNA sensors. Moreover, innate components or pathways exist to sense membrane fusion upon viral entry into host cells. Consequently, this surveillance network activates downstream transcription factors, leading to the induction of type I interferon and inflammatory cytokines. Not surprisingly, with the capacity to establish chronic infection HSV has evolved strategies that modulate or evade innate immunity. In this review, we describe recent advances pertinent to the interplay of HSV and the induction of innate immunity mediated by pathogen recognition receptors or pathways.

Indexed as

AnimalsCytokinesHerpes SimplexHumansImmunity, InnateSimplexvirusToll-Like ReceptorsCytokinesToll-Like Receptorscytokineherpes simplex virusinnate immunityinterferonToll-like receptor

Identifiers

PMID24262390
PMCPMC3943799
OpenAlexW2009818955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.