ArticleProceedings of the National Academy of Sciences of the United States of America2013
Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Acyl-CoA-binding protein as a driver of pathological aging.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Peripheral gating of mechanosensation by glial diazepam binding inhibitor.The Journal of clinical investigation · 2024Article
- Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Optoα1AR activation in astrocytes modulates basal hippocampal synaptic excitation and inhibition in a stimulation-specific manner.Hippocampus · 2023Article
- Integrins Bidirectionally Regulate the Efficacy of Inhibitory Synaptic Transmission and Control GABAergic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus.Nature reviews. Neurology · 2022Review
- Astrocytes: GABAceptive and GABAergic Cells in the Brain.Frontiers in cellular neuroscience · 2022Review
- From benzodiazepines to fatty acids and beyond: revisiting the role of ACBP/DBI.Trends in endocrinology and metabolism: TEM · 2021Review
- αACS chemical neuroscience · 2021Article
- From Physiology to Pathology of Cortico-Thalamo-Cortical Oscillations: Astroglia as a Target for Further Research.Frontiers in neurology · 2021Review
- Variance-adjusted Mahalanobis (VAM): a fast and accurate method for cell-specific gene set scoring.Nucleic acids research · 2020Article
- Differential impacts on multiple forms of spatial and contextual memory in diazepam binding inhibitor knockout mice.Journal of neuroscience research · 2019Article
- Subregion-Specific Impacts of Genetic Loss of Diazepam Binding Inhibitor on Synaptic Inhibition in the Murine Hippocampus.Neuroscience · 2018Article
- Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes.Nature communications · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Microglia Function in the Central Nervous System During Health and Neurodegeneration.Annual review of immunology · 2017Review
- Roles of Glial Cells in Sculpting Inhibitory Synapses and Neural Circuits.Frontiers in molecular neuroscience · 2017Review
- Key Metabolic Enzymes Underlying Astrocytic Upregulation of GABAergic Plasticity.Frontiers in cellular neuroscience · 2017Article
- Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations.Neuron · 2016Review
- Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus.Scientific reports · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Emerging evidence indicates that diazepam-binding inhibitor (DBI) mediates an endogenous benzodiazepine-mimicking (endozepine) effect on synaptic inhibition in the thalamic reticular nucleus (nRT). Here we demonstrate that DBI peptide colocalizes with both astrocytic and neuronal markers in mouse nRT, and investigate the role of astrocytic function in endozepine modulation in this nucleus by testing the effects of the gliotoxin fluorocitrate (FC) on synaptic inhibition and endozepine signaling in the nRT using patch-clamp recordings. FC treatment reduced the effective inhibitory charge of GABAA receptor (GABAAR)-mediated spontaneous inhibitory postsynaptic currents in WT mice, indicating that astrocytes enhance GABAAR responses in the nRT. This effect was abolished by both a point mutation that inhibits classical benzodiazepine binding to GABAARs containing the α3 subunit (predominant in the nRT) and a chromosomal deletion that removes the Dbi gene. Thus, astrocytes are required for positive allosteric modulation via the α3 subunit benzodiazepine-binding site by DBI peptide family endozepines. Outside-out sniffer patches pulled from neurons in the adjacent ventrobasal nucleus, which does not contain endozepines, show a potentiated response to laser photostimulation of caged GABA when placed in the nRT. FC treatment blocked the nRT-dependent potentiation of this response, as did the benzodiazepine site antagonist flumazenil. When sniffer patches were placed in the ventrobasal nucleus, however, subsequent treatment with FC led to potentiation of the uncaged GABA response, suggesting nucleus-specific roles for thalamic astrocytes in regulating inhibition. Taken together, these results suggest that astrocytes are required for endozepine actions in the nRT, and as such can be positive modulators of synaptic inhibition.
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