Evidence map›Paper›PMID 24262118›Full record

ArticleComprehensive psychiatry2014

Validation of a modified version of the PRIME screen for psychosis-risk symptoms in a non-clinical Kenyan youth sample.

Akinkunle Owoso, David M Ndetei, Anne W Mbwayo, Victoria N Mutiso, Lincoln I Khasakhala, Daniel Mamah

Abstract readValidation Study
In one paragraph

Article in Comprehensive psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akinkunle OwosoDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: owosoa@psychiatry.wustl.edu.
David M NdeteiAfrica Mental Health Foundation, Nairobi, Kenya; Department of Psychiatry, University of Nairobi, Kenya.
Anne W MbwayoAfrica Mental Health Foundation, Nairobi, Kenya.
Victoria N MutisoAfrica Mental Health Foundation, Nairobi, Kenya.
Lincoln I KhasakhalaAfrica Mental Health Foundation, Nairobi, Kenya.
Daniel MamahDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.

Funding

Training in the Genetics and Molecular Biology of Mental DisordersT32MH014677 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1985 to 2020
$3.6M
IDENTIFICATION OF PSYCHOSIS-RISK TRAITS IN AFRICAR21MH095645 · NIMH · WASHINGTON UNIVERSITY · PI MAMAH, DANIEL · 2013 to 2014
$270k
NIMH NIH HHS R21 MH095645NIMH NIH HHS T32 MH014677
6 · The paper itself

Abstract

backgroundThe PRIME screen is a self-administered questionnaire designed to quickly assess individuals at risk for developing a psychotic disorder. It is shorter in both length and administration time compared to the Structured Interview for Psychosis-Risk Syndromes (SIPS)-a standard instrument for psychosis prodromal risk assessment. Validation of the PRIME against the SIPS has not been reported in large non-clinical populations.

methodsA culturally modified version of the PRIME screen (mPRIME) was administered to Kenyan youth between the ages of 14 and 29. 182 completed both the SIPS and mPRIME. Validation measures (sensitivity, specificity, positive predictive value, negative predictive value) were calculated and the study sample was then broken down into true positives, false positives, and false negatives for comparison on different quantitative measures.

resultsUsing previously suggested thresholds for a positive screen, the mPRIME had a sensitivity of 40% and a specificity of 64.8% for our entire sample. Positive predictive value (PPV) and negative predictive value (NPV) were 12.3% and 89.7%, respectively. Breaking the sample down by questionnaire outcome showed that true-positive individuals scored higher on average rate and intensity of endorsement of mPRIME items compared to false-positive and false-negatives, while false-negatives on average registered disagreement on all mPRIME questionnaire items.

conclusionsThe mPRIME does not appear to be an effective screener of at-risk individuals for psychosis in our non-clinical sample. Further validation efforts in other general populations are warranted.

Indexed as

AdolescentAdultFemaleHumansKenyaMaleMass ScreeningPredictive Value of TestsPsychiatric Status Rating ScalesPsychometricsPsychotic DisordersRiskSensitivity and SpecificityYoung Adult

Identifiers

PMID24262118
PMCPMC4148134

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.