ArticleCough (London, England)2013
Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial.
Article in Cough (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Diagnosis and Treatment of Adult Patients with Cough.Respiration; international review of thoracic diseases · 2025Guideline
- Bronchitis (acute).BMJ clinical evidence · 2015Pooled it
- The impact of cineole treatment timing on common cold duration and symptoms: Non-randomized exploratory clinical trial.PloS one · 2024Trial
- [Herbal treatment options for post-viral symptoms and long COVID].Wiener medizinische Wochenschrift (1946) · 2026Review
- Expert Opinion: A Call for Early and Appropriate Symptomatic Treatment in Acute Respiratory Infections to Prevent Escalation.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Efficacy and safety of a new drug formulation, amoxicillin-clavulanate-cineole, for adult lower respiratory tract infections: a nationwide observational study in Morocco.Frontiers in pharmacology · 2025Article
- Holistic care in mild upper respiratory tract infections (MURTIs): an approach to individualized care management.Drugs in context · 2025Review
- Antibiotics Usage and Avoidance in Germany and Poland: Attitudes and Knowledge of Patients, Physicians, and Pharmacists.Antibiotics (Basel, Switzerland) · 2024Article
- Investigation into the Effectiveness of an Herbal Combination (AngocinAntibiotics (Basel, Switzerland) · 2024Article
- Potential Saving of Antibiotics for Respiratory Infections in Several European Countries: Insights from Market Research Data.Antibiotics (Basel, Switzerland) · 2023Article
- Rhinosinusitis Treatment with Cineole: Patient-Reported Quality of Life Improvements from a Non-Interventional, Pharmacy-Based Survey.Medicines (Basel, Switzerland) · 2023Article
- Molecular Docking Identifies 1,8-Cineole (Eucalyptol) as A Novel PPARγ Agonist That Alleviates Colon Inflammation.International journal of molecular sciences · 2023Article
- Expression of the Fab enzymes (Fab I and Fab Z) fromJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- Essential Oils and COVID-19.Molecules (Basel, Switzerland) · 2022Review
- Effect of Nebulized Eucalyptus on Arterial Blood Gases and Physiologic Indexes of Mechanical Ventilated Patients: A Randomized Clinical Trial.Journal of caring sciences · 2022Article
- Contribution of Symptomatic, Herbal Treatment Options to Antibiotic Stewardship and Microbiotic Health.Antibiotics (Basel, Switzerland) · 2022Review
- Current Insights on Bioactive Molecules, Antioxidant, Anti-Inflammatory, and Other Pharmacological Activities of Cinnamomum camphora Linn.Oxidative medicine and cellular longevity · 2022Review
- Effects ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Mechanisms, Pathophysiology and Currently Proposed Treatments of Chronic Obstructive Pulmonary Disease.Pharmaceuticals (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCineole has mucolytic, bronchodilating and anti-inflammatory properties and reduces the exacerbation rate in patients suffering from COPD, as well as ameliorates symptoms in patients suffering from asthma and rhinosinusitis. Based on these effects, we therefore postulated the hypothesis that patients with acute bronchitis would also benefit from therapy with Cineole.
methodsAs part of a double-blind, placebo-controlled, multi-center-study, a total of 242 patients with confirmed acute bronchitis was randomly selected to participate. Over a period of 10 days, all patients were administered 3 x 200 mg of Cineole, or a respective placebo, per day. The primary outcome measure was a Bronchitis Sum Score, which summarises the relevant symptoms of acute bronchitis.
resultsAfter 4 days of treatment it was notable, that the patient group treated with Cineole, showed significantly more improvements of the bronchitis-sum-score than those of the placebo group (p = 0.0383). The statistical significant difference of the individual outcome measures was especially underlined by the frequency of cough fits by p = 0.0001 after 4 days.
conclusionsThe effects of Cineole in the treatment of acute bronchitis were clearly measurable and could be proven after a treatment period of merely 4 days. This study corroborates the fact that Cineole actively and significantly reduces cough frequency after four days. Therefore it has been shown to have a great socioeconomic impact. TRIAL REGISTRATION ISRCTN: ISRCTN37784439.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.