Evidence map›Paper›PMID 24260804›Full record

ArticleThe American orthoptic journal2013

The efficacy of botulinum toxin treatment for children with a persistent esotropia following bilateral medial rectus recessions and lateral rectus resections.

Scott R Lambert, Marla J Shainberg

Open access · greenAbstract readComparative Study
In one paragraph

Article in The American orthoptic journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. [Use of botulinum toxin in strabismus].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Scott R Lambert
Marla J Shainberg
Emory University · US

Funding

P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI NICKERSON, JOHN M · 1986 to 2025
$15.3M
NEI NIH HHS EY06360NEI NIH HHS P30 EY006360
6 · The paper itself

Abstract

background and purposeTo report on the outcomes of treating children with a persistent esotropia with an injection of botulinum toxin in a medial rectus muscle. PATIENTS AND

methodsThe medical records were reviewed of all children at one institution with a persistent esotropia after bilateral medial rectus recessions and bilateral lateral rectus resections then treated with a botulinum toxin injection.

resultsFive patients with a mean preoperative esotropia of 37Δ (range 25–50Δ) underwent bilateral medial rectus recessions and then bilateral lateral rectus resections. Their residual esotropia (mean of 25Δ; range 18–35Δ) was then treated with a single injection of 3–5 units of botulinum toxin into one medial rectus muscle. The patients were then followed for a mean of 34 months (range 14–79 months). At last follow-up, two patients had an esotropia <10Δ. The other three patients had no long-term improvement in their ocular alignment. Two of these patients then underwent additional strabismus surgery. In both cases, they then developed a consecutive exotropia.

conclusionTreatment with a single injection of botulinum toxin was beneficial in 2 of 5 children. Botulinum toxin treatment alone did not result in a consecutive exotropia in any patients treated.

Indexed as

Anti-Dyskinesia AgentsBotulinum ToxinsChildEsotropiaEye MovementsFollow-Up StudiesHumansInjections, IntramuscularOculomotor MusclesOphthalmologic Surgical ProceduresRetrospective StudiesTreatment OutcomeVision, BinocularAnti-Dyskinesia AgentsBotulinum Toxins

Identifiers

PMID24260804
PMCPMC4547790
OpenAlexW2059205250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.