ArticlePloS one2013
Could the decision of trial participation precede the informed consent process? Evidence from Burkina Faso.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Factors related to willingness to participate in biomedical research on neglected tropical diseases: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Pooled it
- The willingness to participate in biomedical research involving human beings in low- and middle-income countries: a systematic review.Tropical medicine & international health : TM & IH · 2019Pooled it
- Trial
- Effects of Weekly Iron and Folic Acid Supplements on Malaria Risk in Nulliparous Women in Burkina Faso: A Periconceptional, Double-Blind, Randomized Controlled Noninferiority Trial.The Journal of infectious diseases · 2018Trial
- Cluster randomized trial assessing the effects of rapid ethical assessment on informed consent comprehension in a low-resource setting.BMC medical ethics · 2016Trial
- Community-informed trial design and implementation to optimize recruitment and retention in low-income settings: lessons from rheumatic heart disease trials in Uganda.Frontiers in cardiovascular medicine · 2026Article
- Motivation to participate and experiences of the informed consent process for randomized clinical trials in emergency obstetric care in Uganda.BMC medical ethics · 2021Article
- From informed consent to adherence: factors influencing involvement in mass drug administration with ivermectin for malaria elimination in The Gambia.Malaria journal · 2021Article
- Lay persons' perception of the requirements for research in emergency obstetric and newborn care.BMC medical ethics · 2021Article
- Why 'understanding' of research may not be necessary for ethical emergency research.Philosophy, ethics, and humanities in medicine : PEHM · 2020Review
- Researcher and study participants' perspectives of consent in clinical studies in four referral hospitals in Vietnam.BMC medical ethics · 2020Article
- Clinical trials in low-resource settings: the perspectives of caregivers of paediatric participants from Uganda, Tanzania and Kenya.Tropical medicine & international health : TM & IH · 2019Article
- What motivates Ebola survivors to donate plasma during an emergency clinical trial? The case of Ebola-Tx in Guinea.PLoS neglected tropical diseases · 2018Article
- 'Researchers have love for life': opportunities and barriers to engage pregnant women in malaria research in post-Ebola Liberia.Malaria journal · 2018Article
- Article
- Community approval required for periconceptional adolescent adherence to weekly iron and/or folic acid supplementation: a qualitative study in rural Burkina Faso.Reproductive health · 2018Article
- Cultural considerations for informed consent in paediatric research in low/middle-income countries: a scoping review.BMJ paediatrics open · 2018Article
- "You can save time if…"-A qualitative study on internal factors slowing down clinical trials in Sub-Saharan Africa.PloS one · 2017Article
- Mexican-American perspectives on participation in clinical trials: A qualitative study.Contemporary clinical trials communications · 2016Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver the last years, the number of clinical trials carried out in low-income countries with poor medical infrastructure and limited access to health care has increased. In these settings, the decision of participating in a clinical study may be influenced by factors related to participants' vulnerability that limit the efficacy of the informed consent.
methodsA mixed methods social science study, based on the triangulation of qualitative and quantitative data, was carried out in a socio-economically disadvantaged and semi-urban area of Bobo Dioulasso, Burkina Faso. The study aimed at assessing the relevance of the informed consent procedure on the decision-making process of the parents and/or guardians of potential participants in a pediatric malaria trial.
resultsFor most parents (70.4%), the decision of participating had already been taken before undergoing the informed consent process and was based on the information conveyed through the community. Access to free and good quality health care often inspired this decision. In addition, the parents' willingness to have their child included in the trial made them develop active strategies to achieve this purpose. DISCUSSION: In a context of socio-economic vulnerability and poor access to free health care, the process of informed consent does not always accomplish its goal of informing people and enabling them to make a free and informed decision. This information role is somehow anticipated by the community and trial participation becomes a strategic action to secure otherwise unavailable health resources leading community members to decide on participation even prior to the informed consent process.
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