ArticlePloS one2013
Simultaneous measurement of kidney function by dynamic contrast enhanced MRI and FITC-sinistrin clearance in rats at 3 tesla: initial results.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 28 citations in OpenAlex.
- Multiparametric MRI based assessment of kidney injury in a mouse model of ischemia reperfusion injury.Scientific reports · 2024Article
- Assessment of pharmacologically induced changes in canine kidney function by multiparametric magnetic resonance imaging and contrast enhanced ultrasound.Frontiers in veterinary science · 2024Article
- Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarizedNature communications · 2023Article
- Fibrosis imaging with multiparametric proton and sodium MRI in pig injury models.NMR in biomedicine · 2023Article
- Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging.American journal of physiology. Renal physiology · 2022Article
- Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals.Kidney diseases (Basel, Switzerland) · 2022Review
- Dynamic Contrast Enhancement (DCE) MRI-Derived Renal Perfusion and Filtration: Basic Concepts.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Noninvasive assessment of radiation-induced renal injury in mice.International journal of radiation biology · 2021Article
- Dynamic Contrast Enhanced (DCE) MRI-Derived Renal Perfusion and Filtration: Experimental Protocol.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Measurement of Murine Single-Kidney Glomerular Filtration Rate Using Dynamic Contrast-Enhanced MRI.Magnetic resonance in medicine · 2018Article
- Can HyperpolarizedTomography (Ann Arbor, Mich.) · 2017Article
- Acute kidney function and morphology following topload administration of recombinant hemoglobin solution.Artificial cells, nanomedicine, and biotechnology · 2017Article
- Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease.European journal of pharmacology · 2016Review
- Transcutaneous Assessment of Renal Function in Conscious Rodents.Journal of visualized experiments : JoVE · 2016Article
- Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy.Scientific reports · 2015Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glomerular filtration rate (GFR) is an essential parameter of kidney function which can be measured by dynamic contrast enhanced magnetic resonance imaging (MRI-GFR) and transcutaneous approaches based on fluorescent tracer molecules (optical-GFR). In an initial study comparing both techniques in separate measurements on the same animal, the correlation of the obtained GFR was poor. The goal of this study was to investigate if a simultaneous measurement was feasible and if thereby, the discrepancies in MRI-GFR and optical-GFR could be reduced. For the experiments healthy and unilateral nephrectomised (UNX) Sprague Dawley (SD) rats were used. The miniaturized fluorescent sensor was fixed on the depilated back of an anesthetized rat. A bolus of 5 mg/100 g b.w. of FITC-sinistrin was intravenously injected. For dynamic contrast enhanced perfusion imaging (DCE-MRI) a 3D time-resolved angiography with stochastic trajectories (TWIST) sequence was used. By means of a one compartment model the excretion half-life (t1/2) of FITC-sinistrin was calculated and converted into GFR. GFR from DCE-MRI was calculated by fitting pixel-wise a two compartment renal filtration model. Mean cortical GFR and GFR by FITC-sinistrin were compared by Bland-Altman plots and pair-wise t-test. Results show that a simultaneous GFR measurement using both techniques is feasible. Mean optical-GFR was 4.34 ± 2.22 ml/min (healthy SD rats) and 2.34 ± 0.90 ml/min (UNX rats) whereas MRI-GFR was 2.10 ± 0.64 ml/min (SD rats) and 1.17 ± 0.38 ml/min (UNX rats). Differences between healthy and UNX rats were significant (p<0.05) and almost equal percentage difference (46.1% and 44.3%) in mean GFR were assessed with both techniques. Overall mean optical-GFR values were approximately twice as high compared to MRI-GFR values. However, compared to a previous study, our results showed a higher agreement. In conclusion, the possibility to use the transcutaneous method in MRI may have a huge impact in improving and validating MRI methods for GFR assessment in animal models.
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