ArticlePloS one2013
The development of a preference for cocaine over food identifies individual rats with addiction-like behaviors.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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Who cites it
62 citing papers in PubMed.
- Mechanistic and translational insights from preclinical cocaine choice procedures on the economic substitutability of cocaine and nondrug reinforcers.Neuroscience and biobehavioral reviews · 2025Review
- A Review of Behavioral Economic Manipulations Affecting Drug versus Nondrug Choice in Rats.Perspectives on behavior science · 2025Review
- Time to choose: impact of intertrial interval on selecting between methamphetamine and food reinforcement in male and female rats.Psychopharmacology · 2025Article
- Sex-dependent effects of food-restriction on cocaine self-administration and cocaine-seeking in rats.Frontiers in behavioral neuroscience · 2025Article
- A large-scale c-Fos brain mapping study on extinction of cocaine-primed reinstatement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Sex- and estrous-related response patterns for alcohol depend critically on the level of compulsion-like challenge.Progress in neuro-psychopharmacology & biological psychiatry · 2024Article
- Neuroscience in addiction research.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Practical solutions for including sex as a biological variable (SABV) in preclinical neuropsychopharmacological research.Journal of neuroscience methods · 2024Review
- Effects of isolation housing stress and mouse strain on intravenous cocaine self-administration, sensory stimulus self-administration, and reward preference.Scientific reports · 2023Article
- High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling.Frontiers in public health · 2023Article
- Animal models of compulsion alcohol drinking: Why we love quinine-resistant intake and what we learned from it.Frontiers in psychiatry · 2023Review
- Individual differences in cocaine seeking during voluntary abstinence predicts cocaine relapse and the circuitry mediating relapse.Psychopharmacology · 2022Article
- Drug versus non-drug behaviors: A dual-reward model of sex differences and neurobiological mechanisms in rats.Journal of the experimental analysis of behavior · 2022Article
- Sex differences in the neuroadaptations associated with incubated cocaine-craving: A focus on the dorsomedial prefrontal cortex.Frontiers in behavioral neuroscience · 2022Article
- Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice.Frontiers in neuroscience · 2022Article
- DNA Epigenetics in Addiction Susceptibility.Frontiers in genetics · 2022Review
- Animal Models of the Behavioral Symptoms of Substance Use Disorders.Cold Spring Harbor perspectives in medicine · 2021Review
- A buprenorphine-validated rat model of opioid use disorder optimized to study sex differences in vulnerability to relapse.Psychopharmacology · 2021Article
- Regulation of risky decision making by gonadal hormones in males and females.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Differential importance of nucleus accumbens Ox1Rs and AMPARs for female and male mouse binge alcohol drinking.Scientific reports · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
rationaleCocaine dependence is characterized by compulsive drug taking that supercedes other recreational, occupational or social pursuits. We hypothesized that rats vulnerable to addiction could be identified within the larger population based on their preference for cocaine over palatable food rewards.
objectivesTo validate the choice self-administration paradigm as a preclinical model of addiction, we examined changes in motivation for cocaine and recidivism to drug seeking in cocaine-preferring and pellet-preferring rats. We also examined behavior in males and females to identify sex differences in this "addicted" phenotype.
methodsPreferences were identified during self-administration on a fixed-ratio schedule with cocaine-only, pellet-only and choice sessions. Motivation for each reward was probed early and late during self-administration using a progressive-ratio schedule. Reinstatement of cocaine- and pellet-seeking was examined following exposure to their cues and non-contingent delivery of each reward.
resultsCocaine preferring rats increased their drug intake at the expense of pellets, displayed increased motivation for cocaine, attenuated motivation for pellets and greater cocaine and cue-induced reinstatement of drug seeking. Females were more likely to develop cocaine preferences and recidivism of cocaine- and pellet-seeking was sexually dimorphic.
conclusionsThe choice self-administration paradigm is a valid preclinical model of addiction. The unbiased selection criteria also revealed sex-specific vulnerability factors that could be differentiated from generalized sex differences in behavior, which has implications for the neurobiology of addiction and effective treatments in each sex.
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