ArticlePloS one2013
Potential use of porous titanium-niobium alloy in orthopedic implants: preparation and experimental study of its biocompatibility in vitro.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 83 citations in OpenAlex.
- Exploring the Broad Spectrum of Titanium-Niobium Implants and Hydroxyapatite Coatings-A Review.Materials (Basel, Switzerland) · 2024Review
- Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy.Materials (Basel, Switzerland) · 2023Article
- Niobium promotes fracture healing in rats by regulating the PI3K-Akt signalling pathway: AnJournal of orthopaedic translation · 2022Article
- Electrical Impedance of Surface Modified Porous Titanium Implants with Femtosecond Laser.Materials (Basel, Switzerland) · 2022Article
- Advances in Laser Additive Manufacturing of Ti-Nb Alloys: From Nanostructured Powders to Bulk Objects.Nanomaterials (Basel, Switzerland) · 2021Article
- Development of a Bone-Mimetic 3D Printed Ti6Al4V Scaffold to Enhance Osteoblast-Derived Extracellular Vesicles' Therapeutic Efficacy for Bone Regeneration.Frontiers in bioengineering and biotechnology · 2021Article
- Composite and Surface Functionalization of Ultrafine-Grained Ti23Zr25Nb Alloy for Medical Applications.Materials (Basel, Switzerland) · 2020Article
- Biological and microbiological interactions of Ti-35Nb-7Zr alloy and its basic elements on bone marrow stromal cells: good prospects for bone tissue engineering.International journal of implant dentistry · 2020Article
- Influence of Titanium Alloy Scaffolds on Enzymatic Defense against Oxidative Stress and Bone Marrow Cell Differentiation.International journal of biomaterials · 2020Article
- Osteogenic differentiation of bone marrow-derived mesenchymal stem cells on anodized niobium surface.Journal of materials science. Materials in medicine · 2019Article
- Polydopamine coating promotes early osteogenesis in 3D printing porous Ti6Al4V scaffolds.Annals of translational medicine · 2019Article
- Biomedical Porous Shape Memory Alloys for Hard-Tissue Replacement Materials.Materials (Basel, Switzerland) · 2018Review
- Evaluation of the osteogenesis and osseointegration of titanium alloys coated with graphene: an in vivo study.Scientific reports · 2018Article
- In vitro and in vivo biological performance of porous Ti alloys prepared by powder metallurgy.PloS one · 2018Article
- Laser-modified titanium surfaces enhance the osteogenic differentiation of human mesenchymal stem cells.Stem cell research & therapy · 2017Article
- Novel Bio-functional Magnesium Coating on Porous Ti6Al4V Orthopaedic Implants: In vitro and In vivo Study.Scientific reports · 2017Article
- Article
- Titanium scaffold osteogenesis in healthy and osteoporotic rats is improved by the use of low-level laser therapy (GaAlAs).Lasers in medical science · 2016Article
- New Ti-Alloys and Surface Modifications to Improve the Mechanical Properties and the Biological Response to Orthopedic and Dental Implants: A Review.BioMed research international · 2016Review
- Porous titanium and Ti-35Nb alloy: effects on gene expression of osteoblastic cells derived from human alveolar bone.Journal of materials science. Materials in medicine · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe improvement of bone ingrowth into prosthesis and enhancement of the combination of the range between the bone and prosthesis are important for long-term stability of artificial joints. They are the focus of research on uncemented artificial joints. Porous materials can be of potential use to solve these problems. OBJECTIVES/PURPOSES: This research aims to observe the characteristics of the new porous Ti-25Nb alloy and its biocompatibility in vitro, and to provide basic experimental evidence for the development of new porous prostheses or bone implants for bone tissue regeneration.
methodsThe Ti-25Nb alloys with different porosities were fabricated using powder metallurgy. The alloys were then evaluated based on several characteristics, such as mechanical properties, purity, pore size, and porosity. To evaluate biocompatibility, the specimens were subjected to methylthiazol tetrazolium (MTT) colorimetric assay, cell adhesion and proliferation assay using acridine staining, scanning electron microscopy, and detection of inflammation factor interleukin-6 (IL-6).
resultsThe porous Ti-25Nb alloy with interconnected pores had a pore size of 200 µm to 500 µm, which was favorable for bone ingrowth. The compressive strength of the alloy was similar to that of cortical bone, while with the elastic modulus closer to cancellous bone. MTT assay showed that the alloy had no adverse reaction to rabbit bone marrow mesenchymal stem cells, with a toxicity level of 0 to 1. Cell adhesion and proliferation experiments showed excellent cell growth on the surface and inside the pores of the alloy. According to the IL-6 levels, the alloy did not cause any obvious inflammatory response.
conclusionAll porous Ti-25Nb alloys showed good biocompatibility regardless of the percentage of porosity. The basic requirement of clinical orthopedic implants was satisfied, which made the alloy a good prospect for biomedical application. The alloy with 70% porosity had the optimum mechanical properties, as well as suitable pore size and porosity, which allowed more bone ingrowth.
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