ArticlePloS one2013
Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Circuit-constrained molecular neuroethology in the medicinal leech Hirudo verbana.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- When can neuronal activity-dependent homeostatic plasticity maintain circuit-level properties?Journal of computational neuroscience · 2026Article
- Conductance relationships across compartments associated with bursting output in a model of a motor neuron in the crustacean cardiac ganglion.Journal of neurophysiology · 2026Article
- Morphological details contribute to neuronal response variability within the same cell type.Frontiers in cellular neuroscience · 2026Article
- Rhythm generation, robustness, and control in stick insect locomotion: modeling and analysis.Journal of computational neuroscience · 2025Article
- Dynamics of antiphase bursting modulated by the inhibitory synaptic and hyperpolarization-activated cation currents.Frontiers in computational neuroscience · 2024Article
- A biophysical perspective on the resilience of neuronal excitability across timescales.Nature reviews. Neuroscience · 2023Review
- Neuronal morphology enhances robustness to perturbations of channel densities.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Neuron populations use variable combinations of short-term feedback mechanisms to stabilize firing rate.PLoS biology · 2023Article
- Loss or gain of function? Effects of ion channel mutations on neuronal firing depend on the neuron type.Frontiers in neurology · 2023Article
- Effects of calcium-activated potassium channel modulators on afterhyperpolarizing potentials in identified motor and mechanosensory neurons of the medicinal leech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2021Article
- Circuit Stability to Perturbations Reveals Hidden Variability in the Balance of Intrinsic and Synaptic Conductances.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Network Degeneracy and the Dynamics of Task Switching in the Feeding Circuit inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Ionic current correlations are ubiquitous across phyla.Scientific reports · 2019Article
- A balance of outward and linear inward ionic currents is required for generation of slow-wave oscillations.Journal of neurophysiology · 2017Article
- The neural control of heartbeat in invertebrates.Current opinion in neurobiology · 2016Review
- Consequences of degeneracy in network function.Current opinion in neurobiology · 2016Review
- Dynamic compensation mechanism gives rise to period and duty-cycle level sets in oscillatory neuronal models.Journal of neurophysiology · 2016Article
- Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance.Current opinion in neurobiology · 2016Review
- Distal spike initiation zone location estimation by morphological simulation of ionic current filtering demonstrated in a novel model of an identified Drosophila motoneuron.PLoS computational biology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neurons can have widely differing intrinsic membrane properties, in particular the density of specific conductances, but how these contribute to characteristic neuronal activity or pattern formation is not well understood. To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. We then examined the sensitivity of measures of output activity to conductances and how the model instances responded to hyperpolarizing current injections. We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.