ArticlePloS one2013
Effect of chronic pain on fentanyl self-administration in mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake.Neuropharmacology · 2025Article
- Chronic inflammatory pain reduces fentanyl intake during early acquisition of fentanyl self-administration, but does not change motivation to take fentanyl in male and female rats.Pharmacology, biochemistry, and behavior · 2024Article
- The effects of chronic neuropathic pain on the self-administration of highly potent MOR agonist, fentanyl.bioRxiv : the preprint server for biology · 2024Article
- Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake.bioRxiv : the preprint server for biology · 2024Article
- Neuropathic pain has sex-specific effects on oxycodone-seeking and non-drug-seeking ensemble neurons in the dorsomedial prefrontal cortex of mice.Addiction biology · 2024Article
- Unveiling the link between chronic pain and misuse of opioids and cannabis.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Environmental Enrichment Mitigates the Long-Lasting Sequelae of Perinatal Fentanyl Exposure in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Endogenous opioid systems alterations in pain and opioid use disorder.Frontiers in systems neuroscience · 2022Review
- Lack of effect of different pain-related manipulations on opioid self-administration, reinstatement of opioid seeking, and opioid choice in rats.Psychopharmacology · 2021Article
- Enduring consequences of perinatal fentanyl exposure in mice.Addiction biology · 2021Article
- Article
- GluA1 in Central Amygdala Promotes Opioid Use and Reverses Inhibitory Effect of Pain.Neuroscience · 2020Article
- Fentanyl: Receptor pharmacology, abuse potential, and implications for treatment.Neuroscience and biobehavioral reviews · 2019Review
- A Neurobehavioral Approach to Addiction: Implications for the Opioid Epidemic and the Psychology of Addiction.Psychological science in the public interest : a journal of the American Psychological Society · 2019Review
- Punishment and reinforcement by opioid receptor agonists in a choice procedure in rats.Behavioural pharmacology · 2019Article
- Pain And Opioid Systems, Implications In The Opioid Epidemic.Current opinion in behavioral sciences · 2019Article
- Corticolimbic circuitry in the modulation of chronic pain and substance abuse.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- The effect of quinine in two bottle choice procedures in C57BL6 mice: Opioid preference, somatic withdrawal, and pharmacokinetic outcomes.Drug and alcohol dependence · 2018Article
- Pain Therapy Guided by Purpose and Perspective in Light of the Opioid Epidemic.Frontiers in psychiatry · 2018Review
- Effects of paclitaxel on mechanical sensitivity and morphine reward in male and female C57Bl6 mice.Experimental and clinical psychopharmacology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The development of opioid addiction in subjects with established chronic pain is an area that is poorly understood. It is critically important to clearly understand the neurobiology associated with propensity toward conversion to addiction under conditions of chronic pain. To pose the question whether the presence of chronic pain influences motivation to self-administer opioids for reward, we applied a combination of rodent models of chronic mechanical hyperalgesia and opioid self-administration. We studied fentanyl self-administration in mice under three conditions that induce chronic mechanical hyperalgesia: inflammation, peripheral nerve injury, and repeated chemotherapeutic injections. Responding for fentanyl was compared among these conditions and their respective standard controls (naïve condition, vehicle injection or sham surgery). Acquisition of fentanyl self-administration behavior was reduced or absent in all three conditions of chronic hyperalgesia relative to control mice with normal sensory thresholds. To control for potential impairment in ability to learn the lever-pressing behavior or perform the associated motor tasks, all three groups were evaluated for acquisition of food-maintained responding. In contrast to the opioid, chronic hyperalgesia did not interfere with the reinforcing effect of food. These studies indicate that the establishment of chronic hyperalgesia is associated with reduced or ablated motivation to seek opioid reward in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.