Trial reportPloS one2013
Increased intra-individual variability of cognitive processing in subjects at risk mental state and schizophrenia patients.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability.Molecular psychiatry · 2023Pooled it
- Cognitive function differences across subtypes of first-episode antipsychotic-naïve schizophrenia: insights from event-related potentials.European archives of psychiatry and clinical neuroscience · 2026Article
- Increased intra-subject variability in reward behavior relates to symptom severity in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Mitigating Ethnic Moral Disengagement: The Role of Inhibitory Control, Cognitive Reflection, and Growth-Oriented Personal Values from an Integrative Perspective.Behavioral sciences (Basel, Switzerland) · 2025Article
- Attention-mediated genetic influences on psychotic symptomatology in adolescence.Nature. Mental health · 2024Article
- Predictors of within-individual variability in cognitive performance in schizophrenia in a South African case-control study.Acta neuropsychiatrica · 2023Article
- Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment.Molecular psychiatry · 2023Review
- Within-individual variability in cognitive performance in schizophrenia: A narrative review of the key literature and proposed research agenda.Schizophrenia research · 2023Review
- Altered Effective Connectivity within an Oculomotor Control Network in Unaffected Relatives of Individuals with Schizophrenia.Brain sciences · 2021Article
- Manipulations of the Response-Stimulus Intervals as a Factor Inducing Controlled Amount of Reaction Time Intra-Individual Variability.Brain sciences · 2021Article
- Altered effective connectivity within an oculomotor control network in individuals with schizophrenia.NeuroImage. Clinical · 2021Article
- Cognitive Functioning and Schizotypy: A Four-Years Study.Frontiers in psychiatry · 2020Article
- Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson's disease.NeuroImage. Clinical · 2020Article
- Abnormalities in hubs location and nodes centrality predict cognitive slowing and increased performance variability in first-episode schizophrenia patients.Scientific reports · 2019Article
- Cognitive Variability Predicts Incident Alzheimer's Disease and Mild Cognitive Impairment Comparable to a Cerebrospinal Fluid Biomarker.Journal of Alzheimer's disease : JAD · 2018Article
- Article
- Individual differences in the executive control of attention, memory, and thought, and their associations with schizotypy.Journal of experimental psychology. General · 2016Article
- Response preparation and intra-individual reaction time variability in schizophrenia.Acta medica Lituanic · 2016Article
- Cognitive variability-A marker for incident MCI and AD: An analysis for the Alzheimer's Disease Neuroimaging Initiative.Alzheimer's & dementia (Amsterdam, Netherlands) · 2016Article
- Response inhibition and response monitoring in a saccadic double-step task in schizophrenia.Brain and cognition · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intra-individual variability (IIV) has received recent attention as an indicator of the stability of cognitive functioning that may outperform mean performance in reflecting putative neurobiological abnormalities. Increased IIV is regarded as a core deficit in schizophrenia patients; however, whether this deficit is present in the prodromal phase before the onset of schizophrenia has not been well established. In the present study, we investigated IIV using the stop-signal paradigm in at-risk mental state (ARMS) individuals and in schizophrenia patients. The study included 27 ARMS subjects, 37 schizophrenia patients, and 38 normal controls. The stop-signal task was administered to assess IIV and response inhibition. IIV was estimated by calculating the standard deviation across sub-blocks for the three groups. We observed increased IIV in ARMS subjects and schizophrenia patients compared with normal controls in both the "stop" and the "go" processes even though the mean response inhibition performances were not impaired in the ARMS group. Schizophrenia patients showed impaired response inhibition that was associated with the severity of negative symptoms. Our findings suggest that the analysis of IIV may identify cognitive and clinical features of ARMS that are not detectable by conventional mean performance analysis. The unstable response patterns associated with ARMS may originate from abnormal processing in neural systems caused by alterations in the integrity of functional brain networks and dopamine neuromodulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.