Trial reportPloS one2013
High trait anxiety: a challenge for disrupting fear memory reconsolidation.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Trial
- Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline.Molecular psychiatry · 2018Trial
- Modification of Fear Memory by Pharmacological and Behavioural Interventions during Reconsolidation.PloS one · 2016Trial
- Disrupting reconsolidation of fear memory in humans by a noradrenergic β-blocker.Journal of visualized experiments : JoVE · 2014Trial
- Memory reconsolidation: a proposed change mechanism for the arts therapies.Frontiers in cognition · 2025Article
- A Prelimbic Cortex-Thalamus Circuit Bidirectionally Regulates Innate and Stress-Induced Anxiety-Like Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Bridging the Gap between Psychophysiological and Audiological Factors in the Assessment of Tinnitus: An EEG Investigation in the Beta Band.Brain sciences · 2024Article
- Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala.Journal of affective disorders reports · 2023Article
- Behavioural reconsolidation interference not observed in a within-subjects design.NPJ science of learning · 2022Article
- Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder.International journal of molecular sciences · 2022Review
- Testing the memory reconsolidation hypothesis in a fear extinction paradigm: The effects of ecological and arbitrary stimuli.Learning & behavior · 2022Article
- Perioperative Propranolol Against Dental Anxiety: A Randomized Controlled Trial.Frontiers in psychiatry · 2022Article
- Placebo and Non-specific Effects in Reconsolidation-Based Treatment for Arachnophobia.Frontiers in psychiatry · 2021Article
- The electrophysiology correlation of the cognitive bias in anxiety under uncertainty.Scientific reports · 2020Observational
- Effects of Thryptophan Hydroxylase Blockade by P-Chlorophenylalanine on Contextual Memory Reconsolidation after Training of Different Intensity.International journal of molecular sciences · 2020Article
- Parameters of Memory Reconsolidation: Learning Mode Influences Likelihood of Memory Modification.Frontiers in behavioral neuroscience · 2020Article
- Acute but Not Permanent Effects of Propranolol on Fear Memory Expression in Humans.Frontiers in human neuroscience · 2019Article
- Exploring the boundaries of post-retrieval extinction in healthy and anxious individuals.Behaviour research and therapy · 2018Article
- The Influence of Environmental Enrichment on Cardiovascular and Behavioral Responses to Social Stress.Psychosomatic medicine · 2018Article
- Multiple memory systems, multiple time points: how science can inform treatment to control the expression of unwanted emotional memories.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disrupting reconsolidation may be promising in the treatment of anxiety disorders but the fear-reducing effects are thus far solely demonstrated in the average organism. A relevant question is whether disrupting fear memory reconsolidation is less effective in individuals who are vulnerable to develop an anxiety disorder. By collapsing data from six previous human fear conditioning studies we tested whether trait anxiety was related to the fear-reducing effects of a pharmacological agent targeting the process of memory reconsolidation--n = 107. Testing included different phases across three consecutive days each separated by 24 h. Fear responding was measured by the eye-blink startle reflex. Disrupting the process of fear memory reconsolidation was manipulated by administering the β-adrenergic receptor antagonist propranolol HCl either before or after memory retrieval. Trait anxiety uniquely predicted the fear-reducing effects of disrupting memory reconsolidation: the higher the trait anxiety, the less fear reduction. Vulnerable individuals with the propensity to develop anxiety disorders may need higher dosages of propranolol HCl or more retrieval trials for targeting and changing fear memory. Our finding clearly demonstrates that we cannot simply translate observations from fundamental research on fear reduction in the average organism to clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.