ReviewWorld journal of gastroenterology2013
Pharmacological pain management in chronic pancreatitis.
Review in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Understanding the Pathophysiology of Chronic Pancreatitis: A Comprehensive Review Unraveling Pain Mechanisms and the Role of Psychosocial Factors.Journal of clinical medicine · 2026Review
- Targeted Drug Delivery for the Treatment of Abdominal Pain in Chronic Pancreatitis: A Retrospective Case Series.Cureus · 2024Article
- Advances in the Management of Pain in Chronic Pancreatitis.Current gastroenterology reports · 2023Review
- Evaluating Outcomes and Misuse in Opioid-Dependent Chronic Pancreatitis Using a State-Mandated Monitoring System.Digestive diseases and sciences · 2022Article
- Evidence-Based Approach to the Surgical Management of Acute Pancreatitis.Surgery journal (New York, N.Y.) · 2022Review
- Article
- Medical Management of Chronic Pancreatitis in Children: A Position Paper by the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Pancreas Committee.Journal of pediatric gastroenterology and nutrition · 2021Article
- Predictors, rates, and trends of opioid use disorder among patients hospitalized with chronic pancreatitis.Annals of gastroenterology · 2021Article
- Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats.World journal of gastroenterology · 2019Article
- Patient and Disease Characteristics Associate With Sensory Testing Results in Chronic Pancreatitis.The Clinical journal of pain · 2019Article
- Practical guide to the management of chronic pancreatitis.Frontline gastroenterology · 2019Review
- Systemic inflammation contributes to impairment of quality of life in chronic pancreatitis.Scientific reports · 2019Observational
- Histone deacetylase 2 is involved in µ‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain.Molecular medicine reports · 2018Article
- Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy.World journal of gastroenterology · 2017Article
- Acute physiological and electrical accentuation of vagal tone has no effect on pain or gastrointestinal motility in chronic pancreatitis.Journal of pain research · 2017Article
- Digestive Enzyme Supplementation in Gastrointestinal Diseases.Current drug metabolism · 2016Review
- Surgical Management of Chronic Pancreatitis.The Indian journal of surgery · 2015Article
- Surgical management of chronic pancreatitis: current utilization in the United States.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2015Article
- Understanding and treatment of chronic pancreatitis.World journal of gastroenterology · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intense abdominal pain is a prominent feature of chronic pancreatitis and its treatment remains a major clinical challenge. Basic studies of pancreatic nerves and experimental human pain research have provided evidence that pain processing is abnormal in these patients and in many cases resembles that seen in neuropathic and chronic pain disorders. An important ultimate outcome of such aberrant pain processing is that once the disease has advanced and the pathophysiological processes are firmly established, the generation of pain can become self-perpetuating and independent of the initial peripheral nociceptive drive. Consequently, the management of pain by traditional methods based on nociceptive deafferentation (e.g., surgery and visceral nerve blockade) becomes difficult and often ineffective. This novel and improved understanding of pain aetiology requires a paradigm shift in pain management of chronic pancreatitis. Modern mechanism based pain treatments taking into account altered pain processing are likely to increasingly replace invasive therapies targeting the nociceptive source, which should be reserved for special and carefully selected cases. In this review, we offer an overview of the current available pharmacological options for pain management in chronic pancreatitis. In addition, future options for pain management are discussed with special emphasis on personalized pain medicine and multidisciplinarity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.