ArticleMediators of inflammation2013
Association of serum adiponectin, leptin, and resistin concentrations with the severity of liver dysfunction and the disease complications in alcoholic liver disease.
Article in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Alcohol and the endocrine system: A critical review of disruptions, potential mechanisms, and health implications.Alcohol, clinical & experimental research · 2026Review
- Serum Adiponectin Is Elevated in Critically Ill Patients with Liver Disease and Associated with Decreased Overall Survival.Biomedicines · 2024Article
- Nutritional Support for Alcoholic Liver Disease.Nutrients · 2023Review
- A review of the role of ethanol-induced adipose tissue dysfunction in alcohol-associated liver disease.Alcoholism, clinical and experimental research · 2021Review
- Data on Adiponectin from 2010 to 2020: Therapeutic Target and Prognostic Factor for Liver Diseases?International journal of molecular sciences · 2020Review
- Obesity in acute alcoholic hepatitis increases morbidity and mortality.EBioMedicine · 2019Article
- Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook.Frontiers in pharmacology · 2019Review
- Clinical Therapeutic Effect of Naloxone Combined with Hemodialysis on Acute Severe Alcoholism.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Circulating fibroblast growth factor 21 in patients with liver cirrhosis.Clinical and experimental medicine · 2018Article
- Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations.Nature reviews. Gastroenterology & hepatology · 2018Review
- Adipokines in Liver Cirrhosis.International journal of molecular sciences · 2017Review
- Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis.World journal of gastroenterology · 2017Observational
- Pathophysiology of the Effects of Alcohol Abuse on the Endocrine System.Alcohol research : current reviews · 2017Review
- Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes.World journal of gastroenterology · 2016Review
- Article
- Insulin resistance in clinical and experimental alcoholic liver disease.Annals of the New York Academy of Sciences · 2015Review
- Article
- Angiogenesis-related biomarkers in patients with alcoholic liver disease: their association with liver disease complications and outcome.Mediators of inflammation · 2014Article
- Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThere is growing evidence that white adipose tissue is an important contributor in the pathogenesis of alcoholic liver disease (ALD). We investigated serum concentrations of total adiponectin (Acrp30), leptin, and resistin in patients with chronic alcohol abuse and different grades of liver dysfunction, as well as ALD complications. MATERIALS AND
methodsOne hundred forty-seven consecutive inpatients with ALD were prospectively recruited. The evaluation of plasma adipokine levels was performed using immunoenzymatic ELISA tests. Multivariable logistic regression was applied in order to select independent predictors of advanced liver dysfunction and the disease complications.
resultsAcrp30 and resistin levels were significantly higher in patients with ALD than in controls. Lower leptin levels in females with ALD compared to controls, but no significant differences in leptin concentrations in males, were found. High serum Acrp30 level revealed an independent association with advanced liver dysfunction, as well as the development of ALD complications, that is, ascites and hepatic encephalopathy.
conclusionGender-related differences in serum leptin concentrations may influence the ALD course, different in females compared with males. Serum Acrp30 level may serve as a potential prognostic indicator for patients with ALD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.