ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
The role of the trigeminal sensory nuclear complex in the pathophysiology of craniocervical dystonia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Oral appliances in the treatment of oromandibular dystonia: a systematic review.Acta neurologica Belgica · 2020Pooled it
- Integration of nociceptive activity from orofacial, cranial and cervical regions in the trigeminocervical nucleus: a scoping review with clinical implications.Journal of oral & facial pain and headache · 2025Article
- Exploring the 'EarSwitch' concept: a novel ear based control method for assistive technology.Journal of neuroengineering and rehabilitation · 2024Article
- Brain-Derived Neurotrophic Factor, Nociception, and Pain.Biomolecules · 2024Review
- Anatomical categorization of isolated non-focal dystonia: novel and existing patterns using a data-driven approach.Dystonia (Lausanne, Switzerland) · 2023Article
- Case report: Peripheral nerve stimulation relieves post-traumatic trigeminal neuropathic pain and secondary hemifacial dystonia.Frontiers in neurology · 2023Article
- Protocol for randomized controlled trial to evaluate the safety and feasibility of a novel helmet to deliver transcranial light emitting diodes photobiomodulation therapy to patients with Parkinson's disease.Frontiers in neuroscience · 2022Article
- The Organ of Vision and the Stomatognathic System-Review of Association Studies and Evidence-Based Discussion.Brain sciences · 2021Review
- The Influence of Visual Input on Electromyographic Patterns of Masticatory and Cervical Spine Muscles in Subjects with Myopia.Journal of clinical medicine · 2021Article
- A cross-sectional study of walking, balance and upper limb assessment scales in people with cervical dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2021Observational
- Contemporary clinical neurophysiology applications in dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Standard Correction of Vision Worsens EMG Activity of Pericranial Muscles in Chronic TMD Subjects.Pain research & management · 2020Article
- Psychiatric associations of adult-onset focal dystonia phenotypes.Journal of neurology, neurosurgery, and psychiatry · 2017Article
- Cerebellar Intermittent Theta-Burst Stimulation and Motor Control Training in Individuals with Cervical Dystonia.Brain sciences · 2016Article
- Anodal Direct Current Stimulation of the Cerebellum Reduces Cerebellar Brain Inhibition but Does Not Influence Afferent Input from the Hand or Face in Healthy Adults.Cerebellum (London, England) · 2016Article
- Anodal transcranial direct current stimulation to the cerebellum improves handwriting and cyclic drawing kinematics in focal hand dystonia.Frontiers in human neuroscience · 2015Article
- Diffuse decreased gray matter in patients with idiopathic craniocervical dystonia: a voxel-based morphometry study.Frontiers in neurology · 2014Article
- An Integrative Model Accounting for the Symptom Cluster Triggered After an Acoustic Shock.Trends in hearingReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isolated focal dystonia is a neurological disorder that manifests as repetitive involuntary spasms and/or aberrant postures of the affected body part. Craniocervical dystonia involves muscles of the eye, jaw, larynx, or neck. The pathophysiology is unclear, and effective therapies are limited. One mechanism for increased muscle activity in craniocervical dystonia is loss of inhibition involving the trigeminal sensory nuclear complex (TSNC). The TSNC is tightly integrated into functionally connected regions subserving sensorimotor control of the neck and face. It mediates both excitatory and inhibitory reflexes of the jaw, face, and neck. These reflexes are often aberrant in craniocervical dystonia, leading to our hypothesis that the TSNC may play a central role in these particular focal dystonias. In this review, we present a hypothetical extended brain network model that includes the TSNC in describing the pathophysiology of craniocervical dystonia. Our model suggests the TSNC may become hyperexcitable due to loss of tonic inhibition by functionally connected motor nuclei such as the motor cortex, basal ganglia, and cerebellum. Disordered sensory input from trigeminal nerve afferents, such as aberrant feedback from dystonic muscles, may continue to potentiate brainstem circuits subserving craniocervical muscle control. We suggest that potentiation of the TSNC may also contribute to disordered sensorimotor control of face and neck muscles via ascending and cortical descending projections. Better understanding of the role of the TSNC within the extended neural network contributing to the pathophysiology of craniocervical dystonia may facilitate the development of new therapies such as noninvasive brain stimulation.
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