ArticleAdvanced healthcare materials2014
Pd-porphyrin-cross-linked implantable hydrogels with oxygen-responsive phosphorescence.
Article in Advanced healthcare materials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 53 citations in OpenAlex.
- Oxygels: Tunable Phosphorescent Hydrogels for Cherenkov-Excited Luminescence Imaging (CELI) of Oxygen.Advanced healthcare materials · 2026Article
- Palladium Porphyrin-Modified Fibrin Hydrogel for Oxygen Sensing in Engineered Skin Tissue Applications.ACS omega · 2026Article
- Color-Tunable Room-Temperature Phosphorescence from Non-Aromatic-Polymer-Involved Charge Transfer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- PCL-PEG copolymer based injectable thermosensitive hydrogels.Journal of controlled release : official journal of the Controlled Release Society · 2022Review
- Advanced biomedical hydrogels: molecular architecture and its impact on medical applications.Regenerative biomaterials · 2021Review
- Fluorescence Spectroscopy of Porphyrins and Phthalocyanines: Some Insights into Supramolecular Self-Assembly, Microencapsulation, and Imaging Microscopy.Molecules (Basel, Switzerland) · 2021Review
- Monitoring Oxygen Levels within Large, Tissue-Engineered Constructs Using Porphyin-Hydrogel Microparticles.ACS biomaterials science & engineering · 2019Article
- Functional Supramolecular Gels Based on the Hierarchical Assembly of Porphyrins and Phthalocyanines.Frontiers in chemistry · 2019Review
- Assessing Photosensitizer Targeting Using Meso-Tetra(Carboxyphenyl) Porphyrin.Molecules (Basel, Switzerland) · 2018Article
- Universal sensor array for highly selective system identification using two-dimensional nanoparticles.Chemical science · 2017Article
- Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence.Biomacromolecules · 2017Article
- Surfactant-Stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging.Advanced materials (Deerfield Beach, Fla.) · 2016Article
- A porphyrin-PEG polymer with rapid renal clearance.Biomaterials · 2016Article
- Emerging applications of porphyrins in photomedicine.Frontiers in physics · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Development of long-term implantable luminescent biosensors for subcutaneous oxygen has proved challenging due to difficulties in immobilizing a biocompatible matrix that prevents sensor aggregation yet maintains sufficient concentration for transdermal optical detection. Here, Pd-porphyrins can be used as PEG cross-linkers to generate a polyamide hydrogel with extreme porphyrin density (≈5 × 10(-3) m). Dye aggregation is avoided due to the spatially constraining 3D mesh formed by the porphyrins themselves. The hydrogel exhibits oxygen-responsive phosphorescence and can be stably implanted subcutaneously in mice for weeks without degradation, bleaching, or host rejection. To further facilitate oxygen detection using steady-state techniques, an oxygen-non-responsive companion hydrogel is developed by blending copper and free base porphyrins to yield intensity-matched luminescence for ratiometric detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.