Evidence map›Paper›PMID 24259516›Full record

ReviewPathogens and disease2014

The route less taken: pulmonary models of enteric Gram-negative infection.

Michael L Fisher, Wei Sun, Roy Curtiss

Abstract readReview
In one paragraph

Review in Pathogens and disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael L FisherCenter for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ, USA.
Wei Sun
Roy Curtiss

Funding

Recombinant Attenuated Bacterial Vaccines Against Biodefense AgentsR01AI093348 · NIAID · UNIVERSITY OF FLORIDA · PI CURTISS III, ROY · 2011 to 2015
$5.0M
Attenuated Live and Recombinant Yersinia Pestis VaccinesR01AI057885 · NIAID · WASHINGTON UNIVERSITY · PI CURTISS III, ROY · 2004 to 2014
$4.8M
NIAID NIH HHS 5R01 AI057885NIAID NIH HHS R01 AI057885NIAID NIH HHS R01 AI093348
6 · The paper itself

Abstract

Many pathogens are capable of causing a fulminant infection in pulmonary tissues of mammals. Animal models have provided an extensive understanding of the genetic and molecular mechanisms of bacterial pathogenesis as well as host immune response in the lungs. Many clinically relevant Gram-negative bacteria are host-restricted. Thus, the powerful, informative tools of mouse models are not available for study with these organisms. However, over the past 30 years, enterprising work has demonstrated the utility of pulmonary infection with enteric pathogens. Such infection models have increased our understanding host-pathogen interactions in these organisms. Here, we provide a review and comparison of lung models of infection with enteric, Gram-negative bacteria relative to naturally occurring lung pathogens.

Indexed as

Disease Models, AnimalAnimalsEnterobacteriaceaeEnterobacteriaceae InfectionsMicePneumonia, BacterialGram-negative pathogensrespiratory/lung infection

Identifiers

PMID24259516
PMCPMC3959565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.