ArticleGenome biology and evolution2013
Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Genomic features, metabolism, and biotechnological applications of Candida tropicalis and other non-albicans Candida species.World journal of microbiology & biotechnology · 2026Review
- Profound cell wall remodeling inMicrobiology spectrum · 2026Article
- Antifungal and anti-virulence activities of cinnamon, thyme, and clove essential oils againstFrontiers in pharmacology · 2026Article
- Small pangenome ofmBio · 2025Article
- Emerging fluconazole-resistantFrontiers in microbiology · 2025Article
- PCR-based CRISPR/Cas9 system for fluorescent tagging: A tool for studying Candida parapsilosis virulence.PloS one · 2025Article
- Threats from theMicrobiology and molecular biology reviews : MMBR · 2024Review
- Evaluation of outbreak persistence caused by multidrug-resistant and echinocandin-resistantEmerging microbes & infections · 2024Article
- Follow the Path: Unveiling an Azole ResistantJournal of fungi (Basel, Switzerland) · 2024Article
- Evolution and strain diversity advance exploration ofmSphere · 2024Review
- Article
- Whole-genome sequencing confirms a persistent candidaemia clonal outbreak due to multidrug-resistant Candida parapsilosis.The Journal of antimicrobial chemotherapy · 2023Article
- Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap.The Lancet. Microbe · 2023Review
- Molecular Investigation of the Fatal BloodstreamInternational journal of molecular sciences · 2023Article
- Article
- Candidemia Among Coronavirus Disease 2019 Patients in Turkey Admitted to Intensive Care Units: A Retrospective Multicenter Study.Open forum infectious diseases · 2022Article
- Candidemia among Hospitalized Pediatric Patients Caused by Several Clonal Lineages ofJournal of fungi (Basel, Switzerland) · 2022Article
- Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events.G3 (Bethesda, Md.) · 2022Article
- A New Variant of Mutational and Polymorphic Signatures in theInfection and drug resistance · 2022Article
- Enhancing the chemical transformation ofVirulence · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Candida albicans remains the main cause, the incidence of emerging Candida species, such as C. parapsilosis is increasing. It has been postulated that C. parapsilosis clinical isolates result from a recent global expansion of a virulent clone. However, the availability of a single genome for this species has so far prevented testing this hypothesis at genomic scales. We present here the sequence of three additional strains from clinical and environmental samples. Our analyses reveal unexpected patterns of genomic variation, shared among distant strains, that argue against the clonal expansion hypothesis. All strains carry independent expansions involving an arsenite transporter homolog, pointing to the existence of directional selection in the environment, and independent origins of the two clinical isolates. Furthermore, we report the first evidence for the existence of recombination in this species. Altogether, our results shed new light onto the dynamics of genome evolution in C. parapsilosis.
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