Evidence map›Paper›PMID 24258798›Full record

ArticleMagnetic resonance in medicine2014

Magnetization transfer in lamellar liquid crystals.

Dariya I Malyarenko, Ellen M Zimmermann, Jeremy Adler, Scott D Swanson

Registry-linked trialAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03336983 (Bone Response After Luteinizing Hormone-releasing Hormone Analogue and Enzalutamide +/- Zoledronic Acid in Prostate Cancer Patients With Hormone Sensitive Metastatic Bone Disease), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03336983 phase2completednot on this mapstarted 2017, after this paper: background citation

Bone Response After Luteinizing Hormone-releasing Hormone Analogue and Enzalutamide +/- Zoledronic Acid in Prostate Cancer Patients With Hormone Sensitive Metastatic Bone Disease: a Prospective, Phase II, Randomized, Multicenter Study

TypeinterventionalSponsorAzienda Socio Sanitaria Territoriale degli Spedali Civili di BresciaRan2017 to 2023Enrolled126ConditionsProstate Cancer, Bone MetastasesArmsZoledronic Acid, Enzalutamide
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Probing chemical exchange using quantitative spin-lock RMagnetic resonance in medicine · 2019
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dariya I MalyarenkoDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Ellen M Zimmermann
Jeremy Adler
Scott D Swanson

Funding

Detection of inflammation vs. intestinal fibrosis in Crohn's diseaseR01DK073992 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZIMMERMANN, ELLEN M. · 2007 to 2011
$1.6M
Training Future Imaging Scientists for BiomedicineT32EB005172 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FOWLKES, JEFFREY B · 2008 to 2012
$1.1M
NIBIB NIH HHS T32 EB005172NIDDK NIH HHS R01 DK073992
6 · The paper itself

Abstract

purposeThis study examines the relationship between quantitative magnetization transfer (qMT) parameters and the molecular composition of a model lamellar liquid crystal (LLC) system composed of 1-decyl alcohol (decanol), sodium dodecyl sulfate (SDS), and water.

methodsSamples were made within a stable lamellar mesophase to provide different ratios of total semisolid protons (SDS + decanol) to water protons. Data were collected as a function of radiofrequency power, frequency offset, and temperature. qMT parameters were estimated by fitting a standard model to the data. Fitting results of four different semisolid line shapes were compared.

resultsA super-Lorentzian line shape for the semisolid component provided the best fit. The estimated amount of semisolids was proportional to the ratio of decanol-to-water protons. Other qMT parameters exhibited nonlinear dependence on sample composition. Magnetization transfer ratio (MTR) was a linear function of the semisolid fraction over a limited range of decanol concentration.

conclusionIn LLC samples, MT between semisolid and water originates from intramolecular nOe among decanol aliphatic chain protons followed by proton exchange between decanol hydroxyl and water. Exchange kinetics is influenced by SDS, although SDS protons do not participate in MT. These studies provide clinically relevant range of semisolid fraction proportional to detected MTR.

Indexed as

Fatty AlcoholsLiquid CrystalsModels, TheoreticalNuclear Magnetic Resonance, BiomolecularProtonsSodium Dodecyl SulfateFatty Alcoholsn-decyl alcoholProtonsSodium Dodecyl Sulfatemagnetization transferMRIMT phantomsuper-Lorentzian

Identifiers

PMID24258798
PMCPMC4028438

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.