Observational studyClinical orthopaedics and related research2014
Pain trajectories identify patients at risk of persistent pain after knee arthroplasty: an observational study.
Observational study in Clinical orthopaedics and related research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Repeat Dose Steroid to Prevent Pain Relapse After Total Knee Arthroplasty in Patients With High Pain Response - A Randomized Double-blind Placebo-controlled Trial
Evaluation of the Performance and Safety of the ANTALGEEK® Thess Monitoring Medical Device in the Outpatient Management of Acute Pain and Postoperative Recovery - A Single-Center, Randomized, Controlled Proof-of-Concept Study.
Who cites it
57 citing papers in PubMed, 129 citations in OpenAlex.
- Experiences of recovery and a new care pathway for people with pain after total knee replacement: qualitative research embedded in the STAR trial.BMC musculoskeletal disorders · 2022Trial
- The incidence of persistent postoperative opioid use among U.S. veterans: A national study to identify risk factors.Journal of clinical anesthesia · 2021Trial
- Relationship between acute pain trajectories after an emergency department visit and chronic pain: a Canadian prospective cohort study.BMJ open · 2020Trial
- Patient-reported outcomes, postoperative pain and pain relief after day-case surgery (POPPY): chronic post-surgical pain prevalence and associations.Anaesthesia · 2026Article
- PainDETECT as a Potential Tool for Personalized Medicine: Predicting Outcome One Year After Knee Arthroplasty.Mayo Clinic proceedings. Innovations, quality & outcomes · 2025Article
- Multidimensional pain assessment and opioid use after total knee arthroplasty: continuous vs single-injection regional vs systemic analgesia.Pain reports · 2025Article
- Acute postoperative pain trajectories and their impact on functional recovery following total knee arthroplasty.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Anesthesia Care for Patients Undergoing Total Joint Arthroplasty: A Narrative Review of Disparities in Regional Anesthesia and Recommendations for Future Research Directions.Current anesthesiology reports · 2025Article
- Chronic post-surgical pain after total knee arthroplasty: a narrative review.Perioperative medicine (London, England) · 2024Article
- Evolution and characteristics of nocturnal knee pain after knee arthroplasty.Archives of orthopaedic and trauma surgery · 2024Observational
- Description of pain associated with persistent postoperative pain after total knee arthroplasty.Scientific reports · 2024Article
- Mechanisms and Preventative Strategies for Persistent Pain following Knee and Hip Joint Replacement Surgery: A Narrative Review.International journal of molecular sciences · 2024Review
- The Impact of Acute Postoperative Pain in Developing Chronic Pain after Total Knee Arthroplasty.Neurology international · 2024Article
- Chronic post-surgical pain after knee arthroplasty: a role of peripheral nerve blocks.Frontiers in medicine · 2023Article
- Factors associated with persistent postsurgical pain after total knee or hip joint replacement: a systematic review and meta-analysis.Pain reports · 2023Review
- Pain Course after Total Knee Arthroplasty within a Standardized Pain Management Concept: A Prospective Observational Study.Journal of clinical medicine · 2022Article
- Perioperative Dexmedetomidine or Lidocaine Infusion for the Prevention of Chronic Postoperative and Neuropathic Pain After Gynecological Surgery: A Randomized, Placebo-Controlled, Double-Blind Study.Pain and therapy · 2022Article
- Chronic post-surgical pain - update on incidence, risk factors and preventive treatment options.BJA education · 2022Review
- Predictors and predictive effects of acute pain trajectories after gastrointestinal surgery.Scientific reports · 2022Article
- Influential Factors and Personalized Prediction Model of Acute Pain Trajectories after Surgery for Renal Cell Carcinoma.Journal of personalized medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersistent postsurgical pain is a major source of dissatisfaction after knee arthroplasty. Postoperative pain trajectories allow a dynamic view of pain resolution after surgery and might help to identify patients at risk for persistent pain. QUESTIONS/PURPOSES: In this prospective observational study, we examined the relationship between postoperative pain trajectories and persistent pain, specifically neuropathic pain, at 3 months after knee arthroplasty.
methodsOver a 1-year period, all patients undergoing elective unilateral knee arthroplasty for osteoarthritis by one surgeon were invited to participate in the study, provided they had not had prior knee surgery and their American Society of Anesthesiologists grade was 3 or lower; 128 patients fulfilled these criteria. Patients filled in a diary questioning postoperative pain at rest and during mobilization and maximal pain from Day 1 until Day 8 after surgery. At 3 months, the patients were questioned concerning the presence of persistent pain and its nature and intensity using the Douleur Neuropathique 4 [Neuropathic Pain 4] and Brief Pain Inventory questionnaires. At 3 months, 112 of the 128 patients (87%) were successfully contacted.
resultsAt 3 months, 47 of the 112 (42%) patients were totally pain free and 65 (58%) reported persistent pain at the surgical site. Among the latter, 12 patients (11%) presented with a neuropathic component and more severe persistent pain. Pain trajectories highlighted higher acute pain scores for maximal pain (from Day 1 until Day 8) and for pain at mobilization (from Day 3 until Day 8) in patients with neuropathic persistent pain (p < 0.05 at all time points compared with the no persistent pain group).
conclusionsPostoperative pain trajectories constructed from patient's pain diary suggest that a subgroup of patients who will present with higher pain at 3 months after knee arthroplasty might be identified early in the postoperative period and might benefit from preventative treatment. LEVEL OF EVIDENCE: Level III, diagnostic study. See Instructions for Authors for a complete description of levels of evidence.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.