ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2014
Validation and comparison of 15-D and EQ-5D-5L instruments in a Spanish Parkinson's disease population sample.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Quality of life measures in Parkinson's disease: a systematic literature review of patient-reported outcomes measures (PROMs) and their psychometric properties.Journal of neurology · 2025Pooled it
- Health-related quality of life in Parkinson's disease: systematic review and meta-analysis of EuroQol (EQ-5D) utility scores.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Psychometric properties of the EQ-5D-5L: a systematic review of the literature.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Pooled it
- Health-Related Quality of Life in Patients With Different Diseases Measured With the EQ-5D-5L: A Systematic Review.Frontiers in public health · 2021Pooled it
- Assessment of the construct validity and responsiveness of preference-based quality of life measures in people with Parkinson's: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017Pooled it
- Psychometric properties of the Turkish version of the Parkinson's disease quality of life-7 (PDQoL-7) in older adults.BMC geriatrics · 2026Article
- Burden and disutility of sleep disturbance and early morning OFF symptoms in people with advancing Parkinson's disease: a vignette-based approach using the EQ-5D-5L.Journal of patient-reported outcomes · 2026Article
- Wearable sensor measurements in relation to clinical characteristics and mortality in patients with Parkinson's disease.Neurological research and practice · 2026Article
- From Exhaustion to Empowerment: A Pilot Study on Motor Control-Based Exercise for Fatigue and Quality of Life in Long COVID-19 Patients.Medicina (Kaunas, Lithuania) · 2026Article
- The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study.BMJ open · 2025Article
- Relative contribution of comorbid diseases to health-related quality of life in patients with Parkinson's disease.Journal of patient-reported outcomes · 2024Article
- Hungarian population norms for the 15D generic preference-accompanied health status measure.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- People Diagnosed with Myasthenia Gravis have Lower health-related quality of life and Need More Medical and Caregiver Help in Comparison to the General Population: Analysis of Two Observational Studies.Advances in therapy · 2023Observational
- A head-to-head comparison of the EQ-5D-5L and 15D descriptive systems and index values in a general population sample.Health and quality of life outcomes · 2023Article
- Comparison of quality of life measurements: EQ-5D-5L versus disease/treatment-specific measures in pulmonary embolism and deep vein thrombosis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Converting Parkinson-Specific Scores into Health State Utilities to Assess Cost-Utility Analysis.The patient · 2018Article
- Psychometric properties of the EQ-5D-5L in patients with hip or knee osteoarthritis: reliability, validity and responsiveness.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Validation and comparison of the psychometric properties of the EQ-5D-3L and EQ-5D-5L instruments in Greece.The European journal of health economics : HEPAC : health economics in prevention and care · 2017Article
- Psychometric properties of the EQ-5D-5L in Thai patients with chronic diseases.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo contribute to the ongoing discussion on the choice of a preference-based health-related quality of life (HRQoL) instrument to be used in cost-effectiveness analysis by studying and comparing the validity, sensitivity and relative efficiency of 15-D and EuroQol 5D 5L (EQ-5D-5L) in a Spanish Parkinson's disease (PD) population sample.
methodsOne hundred and thirty-three volunteers were asked to complete an interview using 15-D and EQ-5D-5L. Spearman's rank correlation coefficient (r) was used to test the convergent validity of these instruments with specific PD measures. Sensitivity and efficiency were compared using receiver operating characteristic (ROC) curves and relative efficiency statistic, respectively.
resultsA strong correlation (r > 0.65; p < 0.001) was found between both 15-D and EQ-5D-5L utilities with the summary score of the PDQ-8, and a strong correlation (r > 0.50; p < 0.001) was found between 15-D and EQ-5D-5L utilities with the EQ-VAS. The areas under the ROC of both instruments all exceeded 0.5 (p < 0.001). The 15-D instrument was 4.1-29.8 % less efficient at detecting differences between patients with optimal HRQoL, while this instrument was 11 % more efficient at detecting differences between patients at mild and moderate to strong severity of the PD symptoms.
conclusions15-D and EQ-5D-5L are showed to be valid and sensitivity generic HRQoL measures in Spanish PD patients with both instruments showing similar HRQoL dimension coverage and ceiling/floor effects. The 15-D has better efficiency and greater sensitivity to detect clinical changes in PD severity of the symptoms meanwhile the EQ-5D-5L is better to detect clinical HRQoL changes. Additionally, the EQ-5D-5L questionnaire requires less time than 15-D to be administered, and it might be more appropriate for studies conducted in Spain, since a country-specific "value set" is available for this instrument and not for the 15-D.
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