ArticleIn vitro cellular & developmental biology. Animal2014
Upregulation of GM-CSF by TGF-β1 in epithelial mesenchymal transition of human HERS/ERM cells.
Article in In vitro cellular & developmental biology. Animal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- About a Possible Impact of Endodontic Infections byInternational journal of molecular sciences · 2024Review
- Gene and protein interaction network analysis in the epithelial-mesenchymal transition of Hertwig's Epithelial Root Sheath reveals periodontal regenerative drug targets - An in silico study.Saudi journal of biological sciences · 2022Article
- Analysis of the cells isolated from epithelial cell rests of Malassez through single-cell limiting dilution.Scientific reports · 2022Article
- Mechanism of Emodin in the Treatment of Rheumatoid Arthritis.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Isolation and characterization of dental follicle-derived Hertwig's epithelial root sheath cells.Clinical oral investigations · 2021Article
- Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis.Cancers · 2021Article
- Expression dynamics of integrin α2, α3, and αV upon osteogenic differentiation of human mesenchymal stem cells.Stem cell research & therapy · 2020Article
- Amelogenic transcriptome profiling in ameloblast-like cells derived from adult gingival epithelial cells.Scientific reports · 2019Article
- Comparative study on differentiation of cervical-loop cells and Hertwig's epithelial root sheath cells under the induction of dental follicle cells in rat.Scientific reports · 2018Article
- Loss of Stemness, EMT, and Supernumerary Tooth Formation in CebpbScientific reports · 2018Article
- SPARC and the N-propeptide of collagen I influence fibroblast proliferation and collagen assembly in the periodontal ligament.PloS one · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hertwig's epithelial root sheath/epithelial rests of Malassez (HERS/ERM) have been suggested to play an important role in tooth root formation, particularly in periodontal development. Epithelial mesenchymal transition (EMT) has been suggested to contribute to root development in tooth. However, the mechanism of interaction between HERS/ERM cells and dental mesenchymal cells has not been fully understood. In this study, we investigated the effect of exogenous transforming growth factor beta 1 (TGF-β1) in human HERS/ERM cells in order to verify the role of granulocyte macrophage colony-stimulating factor (GM-CSF) in EMT process. Antibody array was used to screen secretion factors by exogenous TGF-β1. Secretion of GM-CSF was increased by exogenous TGF-β1. Expression levels of EMT markers, vimentin, ZEB1 (zinc finger E-box binding homeobox 1), and E-cadherin, were confirmed using reverse transcription polymerase chain reaction and immunocytochemistry. Treatment with GM-CSF increased the expression of vimentin and ZEB1, similar to TGF-β1 treatment, and decreased the expression of E-cadherin. Our results suggest that GM-CSF could induce EMT in human HERS/ERM cells.
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Registered trials
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