ArticleJournal of neuro-oncology2014
Skull base meningiomas: neurological outcome after microsurgical resection.
Article in Journal of neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Identification of key elements in MRI reporting of intracranial meningiomas based on a nationwide survey of clinical experts in Germany.Scientific reports · 2025Article
- Article
- Role of risk factors, scoring systems, and prognostic models in predicting the functional outcome in meningioma surgery: multicentric study of 552 skull base meningiomas.Neurosurgical review · 2023Article
- Are there predilection sites for intracranial meningioma? A population-based atlas.Neurosurgical review · 2022Article
- Review
- A new scoring system for predicting extent of resection in medial sphenoid wing meningiomas based on three-dimensional multimodality fusion imaging.Chinese neurosurgical journal · 2020Article
- The pretemporal trans-cavernous trans-Meckel's trans-tentorial trans-petrosal approach: a combo skill in treating skull base meningiomas.Journal of neuro-oncology · 2020Observational
- Long-Term Clinical Outcome of First Recurrence Skull Base Meningiomas.Journal of clinical medicine · 2019Article
- Skull base versus non-skull base meningioma surgery in the elderly.Neurosurgical review · 2019Article
- Meningiomas: skull base versus non-skull base.Neurosurgical review · 2019Article
- Cranial nerve outcomes after primary stereotactic radiosurgery for symptomatic skull base meningiomas.Journal of neuro-oncology · 2018Article
- Incidence, Clinico-Radiological Features and Outcome of Skull Base versus Non-Skull Base Meningiomas Treated in Kuala Lumpur General Hospital: A Five-Year Experience.The Malaysian journal of medical sciences : MJMS · 2018Article
- The Simpson grading in meningioma surgery: does the tumor location influence the prognostic value?Journal of neuro-oncology · 2017Article
- A comparison of clinicopathological features and surgical outcomes between pediatric skull base and non-skull base meningiomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Long Term Surgical Outcome and Prognostic Factors of Atypical and Malignant Meningiomas.Scientific reports · 2016Article
- How to compare clinical results of different neurosurgical centers? Is a classification of complications in neurosurgery necessary for this purpose?Surgical neurology international · 2016Article
- Article
- Minimally invasive surgery of the anterior skull base: transorbital approaches.GMS current topics in otorhinolaryngology, head and neck surgery · 2015Review
- How Important Is to Know the Psychosocial Performance in an Operated Child of Meningioma?Journal of pediatric neurosciencesArticle
- Tumor recurrence in parasagittal and falcine atypical meningiomas invading the superior sagittal sinus.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microsurgical resection is the primary treatment of skull base meningiomas. Maximal resection provides the best tumor control rates but can be associated with high surgical morbidity. To understand the relation between extent of resection (EOR) and functional outcome we have analyzed the neurological improvement and recurrence rate in a large consecutive series of skull base meningioma patients. In addition, we defined anatomical and biological factors predictive for recurrence and overall outcome. We investigated 226 skull base meningioma patients receiving tumor resection in our institution. The most frequent location was the medial sphenoid ridge (29.6 %). EOR was rated according to the Simpson scale. Overall performance was measured by the Karnofsky performance score (KPS); neurological deficits were quantified using the Medical Research Council Neurological Severity Score (MRC-NPS). Complete resection was achieved in 62.8 % and the EOR was significantly correlated to tumor location. The morbidity and mortality rate was 32.1 and 2.7 % respectively, new permanent neurological deficits occurred in 3.5 % of all patients. From all patients with focal neurological deficits, 60.1 % experienced significant improvement. Both the MRC-NPS and the KPS significantly improved from the preoperative status to discharge, however the improvement rate was dependent on the tumor location. Recurrence rate was 15.5 %; tumor size, bone- and venous sinus infiltration, WHO grade, poor EOR but not MIB-1 labeling index were independent factors predictive for recurrence. Microsurgical resection of skull base meningiomas improves neurological impairment in the majority of patients. Specific risk factors for recurrence require consideration for postoperative management.
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