ArticleAnnals of clinical microbiology and antimicrobials2013
Functional verification of computationally predicted qnr genes.
Article in Annals of clinical microbiology and antimicrobials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Distribution and genetic characterization of fluoroquinolone resistance geneMicrobiology spectrum · 2024Article
- Latent antibiotic resistance genes are abundant, diverse, and mobile in human, animal, and environmental microbiomes.Microbiome · 2023Article
- A Novel, Integron-Regulated, Class C β-Lactamase.Antibiotics (Basel, Switzerland) · 2020Article
- Palmatine Is a Plasmid-Mediated Quinolone Resistance (PMQR) Inhibitor That Restores the Activity of Ciprofloxacin Against QnrS and AAC(6')-Ib-cr-ProducingInfection and drug resistance · 2020Article
- Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes.Microbiome · 2019Article
- Identification and reconstruction of novel antibiotic resistance genes from metagenomes.Microbiome · 2019Article
- Phenotypic and genotypic characteristics ofPorcine health management · 2019Article
- Discovery of the fourth mobile sulfonamide resistance gene.Microbiome · 2017Article
- Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets.BMC genomics · 2017Article
- Next-generation approaches to understand and combat the antibiotic resistome.Nature reviews. Microbiology · 2017Review
- Occurrence ofGut pathogens · 2017Article
- Resistance Mutations in gyrA and parC are Common in Escherichia Communities of both Fluoroquinolone-Polluted and Uncontaminated Aquatic Environments.Frontiers in microbiology · 2015Article
- Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India.Frontiers in microbiology · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe quinolone resistance (qnr) genes are widely distributed among bacteria. We recently developed and applied probabilistic models to identify tentative novel qnr genes in large public collections of DNA sequence data including fragmented metagenomes.
findingsBy using inducible recombinant expressions systems the functionality of four identified qnr candidates were evaluated in Escherichia coli. Expression of several known qnr genes as well as two novel candidates provided fluoroquinolone resistance that increased with elevated inducer concentrations. The two novel, functionally verified qnr genes are termed Vfuqnr and assembled qnr 1. Co-expression of two qnr genes suggested non-synergistic action.
conclusionThe combination of a computational model and recombinant expression systems provides opportunities to explore and identify novel antibiotic resistance genes in both genomic and metagenomic datasets.
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