ArticleNature chemistry2013
Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes.
Article in Nature chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed.
- Synthetic polymers promote cell aggregation and accelerate cathode-associated layer formation inBiofilm · 2026Article
- Contrasting Biofilm-Modulating Effects of Polymeric Quaternary Ammonium Compounds on the Pathogenic YeastsACS omega · 2026Article
- Pyrgos[Science advances · 2024Article
- Magnetic Microrobot Swarms with Polymeric Hands Catching Bacteria and Microplastics in Water.ACS nano · 2024Article
- Influence of Surface Roughness, Nanostructure, and Wetting on Bacterial Adhesion.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Polymer-induced biofilms for enhanced biocatalysis.Materials horizons · 2022Article
- Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow.Chemical Society reviews · 2022Review
- Engineered microorganism-based delivery systems for targeted cancer therapy: a narrative review.Biomaterials translational · 2022Review
- Picking the right metaphors for addressing microbial systems: economic theory helps understanding biological complexity.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
- Nutrient Element Decorated Polyetheretherketone Implants Steer Mitochondrial Dynamics for Boosted Diabetic Osseointegration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- The role of polymers in cross-kingdom bioadhesion.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Solution-Mediated Modulation ofAntibiotics (Basel, Switzerland) · 2019Article
- Switch Catalysis To Deliver Multi-Block Polyesters from Mixtures of Propene Oxide, Lactide, and Phthalic Anhydride.Angewandte Chemie (International ed. in English) · 2018Article
- Aggregation of Vibrio cholerae by Cationic Polymers Enhances Quorum Sensing but Overrides Biofilm Dissipation in Response to Autoinduction.ACS chemical biology · 2018Article
- Photochemical "In-Air" Combinatorial Discovery of Antimicrobial Co-polymers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Focusing quorum sensing signalling by nano-magnetic assembly.Environmental microbiology · 2018Article
- Implementation of Blue Light Switchable Bacterial Adhesion for Design of Biofilms.Bio-protocol · 2018Article
- Article
- Multivalent Antimicrobial Polymer Nanoparticles Target Mycobacteria and Gram-Negative Bacteria by Distinct Mechanisms.Biomacromolecules · 2018Article
- Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation inChemical science · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one method by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can interfere with bacterial adhesion or the chemical reactions used for quorum sensing are therefore a potential means to control bacterial population responses. Here, we report how polymeric 'bacteria sequestrants', designed to bind to bacteria through electrostatic interactions and therefore inhibit bacterial adhesion to surfaces, induce the expression of quorum-sensing-controlled phenotypes as a consequence of cell clustering. A combination of polymer and analytical chemistry, biological assays and computational modelling has been used to characterize the feedback between bacteria clustering and quorum sensing signalling. We have also derived design principles and chemical strategies for controlling bacterial behaviour at the population level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.