ArticleNature chemistry2013
Pattern transformation with DNA circuits.
Article in Nature chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
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- Translating Nature's Design Rules: How Catalysis and Life Science Guide Molecular Catassembly.JACS Au · 2026Review
- Inverted Molecular Beacons as Reaction-Based Hybridization Probes for Small-Molecule Activation by Nucleic Acid Inputs.ACS chemical biology · 2025Article
- Scaling-up molecular logic to meso-systems via self-assembly.Nature communications · 2025Article
- Directing Nanoparticle Organization in Response to Diverse Chemical Inputs.Journal of the American Chemical Society · 2024Article
- Tipping-point transition from transient to persistent inflammation in pancreatic islets.NPJ systems biology and applications · 2024Article
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- DNA Logic Gates for Small Molecule Activation Circuits in Cells.ACS synthetic biology · 2024Article
- Article
- 4D Biochemical Photocustomization of Hydrogel Scaffolds for Biomimetic Tissue Engineering.Accounts of materials research · 2023Article
- Recent advances in cascade isothermal amplification techniques for ultra-sensitive nucleic acid detection.Talanta · 2023Review
- An 8-bit monochrome palette of fluorescent nucleic acid sequences for DNA-based painting.Nanoscale · 2022Article
- A model of spatio-temporal regulation within biomaterials using DNA reaction-diffusion waveguides.Royal Society open science · 2022Article
- Signal-processing and adaptive prototissue formation in metabolic DNA protocells.Nature communications · 2022Article
- Programmed mechano-chemical coupling in reaction-diffusion active matter.Science advances · 2021Article
- A CRISPR-based and post-amplification coupled SARS-CoV-2 detection with a portable evanescent wave biosensor.Biosensors & bioelectronics · 2021Article
- Spatiotemporal patterning of photoresponsive DNA-based hydrogels to tune local cell responses.Nature communications · 2021Article
- Polymerization and isomerization cyclic amplification for nucleic acid detection with attomolar sensitivity.Chemical science · 2021Article
- l-DNA Duplex Formation as a Bioorthogonal Information Channel in Nucleic Acid-Based Surface Patterning.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Accelerating the Finite-Element Method for Reaction-Diffusion Simulations on GPUs with CUDA.Micromachines · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
Readily programmable chemical networks are important tools as the scope of chemistry expands from individual molecules to larger molecular systems. Although many complex systems are constructed using conventional organic and inorganic chemistry, the programmability of biological molecules such as nucleic acids allows for precise, high-throughput and automated design, as well as simple, rapid and robust implementation. Here we show that systematic and quantitative control over the diffusivity and reactivity of DNA molecules yields highly programmable chemical reaction networks (CRNs) that execute at the macroscale. In particular, we designed and implemented non-enzymatic DNA circuits capable of performing pattern-transformation algorithms such as edge detection. We also showed that it is possible to fine-tune and multiplex such circuits. We believe these strategies will provide programmable platforms on which to prototype CRNs, discover bottom-up construction principles and generate patterns in materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.