ArticleActa veterinaria Scandinavica2013
An enzyme-linked immunosorbent assay for detection of avian influenza virus subtypes H5 and H7 antibodies.
Article in Acta veterinaria Scandinavica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Highly pathogenic avian influenza H5 clade 2.3.4.4 and human new pandemic H1N1 virus exposure in domestic cats with outdoor access in the Netherlands in 2024.Journal of feline medicine and surgery · 2026Article
- Evaluation of the Effect of Pb Pollution on Avian Influenza Virus-Specific Antibody Production in Black-Headed Gulls (Animals : an open access journal from MDPI · 2023Article
- Development of a recombinase-aided amplification combined with a lateral flow dipstick assay for rapid detection of H7 subtype avian influenza virus.Frontiers in microbiology · 2023Article
- A novel epitope-blocking ELISA for specific and sensitive detection of antibodies against H5-subtype influenza virus hemagglutinin.Virology journal · 2021Article
- Co-inections of domestic and wild birds with avian influenza and Newcastle disease viruses: implications for control and genetic mutations.Veterinary research communications · 2020Article
- Seroepidemiology and assessment of risk factors for the spread of avian influenza in birds in two Nigerian states.Veterinary medicine and science · 2017Article
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAvian influenza virus (AIV) subtypes H5 and H7 attracts particular attention because of the risk of their potential pathogenicity in poultry. The haemagglutination inhibition (HI) test is widely used as subtype specific test for serological diagnostics despite the laborious nature of this method. However, enzyme-linked immunosorbent assays (ELISAs) are being explored as an alternative test method.H5 and H7 specific monoclonal antibodies were experimentally raised and used in the development of inhibition ELISAs for detection of serological response specifically directed against AIV subtypes H5 and H7. The ELISAs were evaluated with polyclonal chicken anti-AIV antibodies against AIV subtypes: H1N2, H5N2, H5N7, H7N1, H7N7, H9N9, H10N4 and H16N3.
resultsBoth the H5 and H7 ELISA proved to have a high sensitivity and specificity and the ELISAs detected H5 and H7 antibodies earlier during experimental infection than the HI test did. The reproducibility of the ELISA's performed at different times was high with Pearson correlation coefficients of 0.96-0.98.
conclusionsThe ELISAs are a potential alternative to the HI test for screening of large amounts of avian sera, although only experimental sera were tested in this study.
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