ArticleBiochemical Society transactions2013
Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease.
Article in Biochemical Society transactions, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Review
- Membrane Interactions of α-Synuclein Probed by Neutrons and Photons.Accounts of chemical research · 2021Article
- Article
- C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease.The Journal of biological chemistry · 2019Article
- A pH-dependent switch promotes β-synuclein fibril formation via glutamate residues.The Journal of biological chemistry · 2017Article
- Iron and Neurodegeneration: Is Ferritinophagy the Link?Molecular neurobiology · 2016Review
- Bypassing the blood-brian barrier using established skull base reconstruction techniques.World journal of otorhinolaryngology - head and neck surgery · 2015Review
- Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C.Biochemical and biophysical research communications · 2015Article
- Structural features of membrane-bound glucocerebrosidase and α-synuclein probed by neutron reflectometry and fluorescence spectroscopy.The Journal of biological chemistry · 2015Article
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Authors and funding
2 authors.
Funding
Abstract
Mutations in the GBA1 gene, encoding the enzyme glucocerebrosidase, cause the lysosomal storage disorder GD (Gaucher's disease), and are associated with the development of PD (Parkinson's disease) and other Lewy body disorders. Interestingly, GBA1 variants are the most common genetic risk factor associated with PD. Although clinical studies argue a strong case towards a link between GBA1 mutations and the development of PD, mechanistic insights have been lacking. In the present article, we review recent findings that have provided some biochemical evidence to bridge this relationship, focusing on the molecular link between two proteins, α-synuclein and glucocerebrosidase, involved in PD and GD respectively.
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