ArticleWorld journal of psychiatry2013
New findings in the genetics of schizophrenia.
Article in World journal of psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identifying causal associations between women's reproductive traits and risk of schizophrenia: a multivariate validated two-sample Mendelian randomization analysis.BMC psychiatry · 2024Pooled it
- Brain Transcriptome Changes Associated With an Acute Increase of Protein O-GlcNAcylation and Implications for Neurodegenerative Disease.Journal of neurochemistry · 2025Article
- Predictive factors and symptom severity spectrum in adult schizophrenia: Potential insights for improved management and adequate care.Biomedical reports · 2024Article
- Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization.Experimental & molecular medicine · 2023Review
- Gene-Environment Interactions in Major Mental Disorders in the Czech Republic.Neuropsychiatric disease and treatment · 2020Article
- Expression analysis and genotyping of DGKZ: a GWAS-derived risk gene for schizophrenia.Molecular biology reports · 2019Article
- Psychosocial Stress Induces Schizophrenia-Like Behavior in Mice With Reduced MMP-9 Activity.Frontiers in behavioral neuroscience · 2019Article
- Narrowing the Genetic Causes of Language Dysfunction in the 1q21.1 Microduplication Syndrome.Frontiers in pediatrics · 2018Article
- Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports.American journal of medical genetics. Part A · 2016Article
- Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis.Molecular neurobiology · 2016Article
- DNA methylation changes in the placenta are associated with fetal manganese exposure.Reproductive toxicology (Elmsford, N.Y.) · 2015Article
- Genetic analysis of common variants in the HDAC2 gene with schizophrenia susceptibility in Han Chinese.Journal of human genetics · 2015Article
- Meta-analyses of 10 polymorphisms associated with the risk of schizophrenia.Biomedical reports · 2014Article
- Article
- DLG5 in cell polarity maintenance and cancer development.International journal of biological sciences · 2014Review
- Psychiatry 2050: from younger psychiatrists' perspective.Neuropsychiatric disease and treatment · 2014Article
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Abstract
New findings in schizophrenia genetics are based on genome-wide association studies (GWAS), research into DNA copy number variations (CNVs), and endophenotypes. More than 70 genes have recently been suspected to be involved in the genetic background of schizophrenia based on the GWAS´s results. They are typically related to neurodevelopment/neuroplasticity, immunology and neuroendocrinology. Nevertheless, for many detected genes their possible relationship to schizophrenia etiopathogenesis is still unknown. The CNVs at genome loci 1q21.1 (candidate gene e.g., PRKAB2), 2p16.3 (candidate gene e.g., NRXN1), 3q29 (candidate genes e.g., BDH1, DLG1, PAK2 or TFRC), 15q11.2 (candidate gene e.g., CYFIP1), 15q13.3 (candidate gene e.g., CHRNA7), 16p13.1 (candidate genes e.g.,NTAN1 or NDE1) and 22q11.2 (candidate genes e.g., COMT, GSTT2 or PRODH) were associated with schizophrenia most frequently. Genetic research of schizophrenia endophenotypes, usually neurophysiological, neuromotoric, neurocognitive, neuroanatomical, neurological or personality-related, will help us to discover the role of relevant genes in the pathogenesis of schizophrenia. It is also necessary to integrate knowledge from other research platforms in schizophrenia, like epigenetics, studies of gene-environment interactions, transcriptomics, proteomics, metabolomics, neuroimaging and psychopathology. A better knowledge of the genetic background of schizophrenia can lead to changes in the treatment, prevention and genetic counselling. It may also reduce stigma in this severe mental disorder.
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