ArticleSpringerPlus2013
Use of the kidney injury molecule-1 as a biomarker for early detection of renal tubular dysfunction in a population chronically exposed to cadmium in the environment.
Article in SpringerPlus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Urinary KIM-1: a novel biomarker for evaluation of occupational exposure to lead.Scientific reports · 2016Trial
- The Protective Potential ofInternational journal of molecular sciences · 2023Article
- Relationship between urinary biomarkers of early kidney damage and exposure to inorganic toxins in a pediatric population of Apizaco, Tlaxcala, Mexico.Journal of nephrology · 2023Article
- Dose-Response Analysis of the Tubular and Glomerular Effects of Chronic Exposure to Environmental Cadmium.International journal of environmental research and public health · 2022Article
- Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health.Biomarker insights · 2022Review
- Association between Enzyme-Linked Immunosorbent Assay-Measured Kidney Injury Markers and Urinary Cadmium Levels in Chronic Kidney Disease.Journal of clinical medicine · 2021Article
- Renal impairment assessment on adults living nearby a landfill: Early kidney dysfunction biomarkers linked to the environmental exposure to heavy metals.Toxicology reports · 2021Article
- Review
- Ammonium Pyrrolidine Dithiocarbamate-Modified CdTe/CdS Quantum Dots as a Turn-on Fluorescent Sensor for Detection of Trace Cadmium Ions.Sensors (Basel, Switzerland) · 2020Article
- Environmental and Occupational Exposures in Kidney Disease.Seminars in nephrology · 2019Review
- Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study.Clinical proteomics · 2019Article
- Dietary Cadmium Intake and Its Effects on Kidneys.Toxics · 2018Review
- Cadmium exposure and age-associated DNA methylation changes in non-smoking women from northern Thailand.Environmental epigenetics · 2017Article
- Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand.International journal of environmental research and public health · 2017Article
- Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1.Environmental research · 2016Article
- Evaluation of cystatin C as an early biomarker of cadmium nephrotoxicity in the rat.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2016Article
- DNA methylation is differentially associated with environmental cadmium exposure based on sex and smoking status.Chemosphere · 2016Article
- Kidney injury molecule-1 as a predicting factor for inflamed kidney, diabetic and diabetic nephropathy Egyptian patients.Journal of diabetes and metabolic disorders · 2015Article
- Risk assessment for Thai population: benchmark dose of urinary and blood cadmium levels for renal effects by hybrid approach of inhabitants living in polluted and non-polluted areas in Thailand.BMC public health · 2014Article
- A biomarker found in cadmium exposed residents of Thailand by metabolome analysis.International journal of environmental research and public health · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cadmium (Cd) has been found as an environmental pollutant in Mae Sot district, Tak province, Thailand. Prolong exposure to high levels of Cd of the resident increases high risk of Cd toxicity especially to kidney which is the primary target of Cd. In order to investigate the early effect of Cd induced renal dysfunction, a kidney injury molecule-1 (KIM-1), a novel biomarker of renal tubular dysfunction, was measured using an enzyme linked immunosorbent assay (ELISA). The method was validated and used to quantify the KIM-1 concentrations in the urine of 700 subjects (260 men, 440 women) who lived in the Cd contaminated area. The KIM-1 concentrations were compared to the concentrations of two conventional renal tubular dysfunction biomarkers, N-acetyl-β-D-glucosaminidase (NAG) and β2-microglobulin (β2-MG). Urinary KIM-1 was correlated with urinary and blood Cd as well as NAG. After adjustment of age and smoking, urinary KIM-1 was correlated with blood Cd more than urinary NAG did. Clear dose response relationships of urinary KIM-1 with urinary Cd were shown in both men and women. These results indicate that the urinary KIM-1 might be more sensitive biomarker than urinary NAG and β2-MG for an early detection of renal tubular dysfunction. It is useful as a tool to detect renal effect of toxicity due to chronic Cd exposure at high level.
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