ArticleTremor and other hyperkinetic movements (New York, N.Y.)2013
Lessons Learned from Open-label Deep Brain Stimulation for Tourette Syndrome: Eight Cases over 7 Years.
Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Target-Specific Effects of Deep Brain Stimulation for Tourette Syndrome: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Deep Brain Stimulation in Treatment-Resistant Psychiatric Disorders: Efficacy, Safety, and Future Directions.Brain sciences · 2025Review
- Deep brain stimulation for Tourette's syndrome.Neurosurgical review · 2024Review
- Improved depressive symptoms in patients with refractory Gilles de la Tourette syndrome after deep brain stimulation of posteroventral globus pallidus interna.Brain and behavior · 2022Article
- European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part IV: deep brain stimulation.European child & adolescent psychiatry · 2022Review
- Therapeutic Neurostimulation in Obsessive-Compulsive and Related Disorders: A Systematic Review.Brain sciences · 2021Review
- Economic evaluation of deep-brain stimulation for Tourette's syndrome: an initial exploration.Journal of neurology · 2019Article
- Deep brain stimulation in Tourette's syndrome: evidence to date.Neuropsychiatric disease and treatment · 2019Review
- The Use of Deep Brain Stimulation in Tourette Syndrome.Brain sciences · 2016Review
- Why so many deep brain stimulation targets in Tourette's syndrome? Toward a broadening of the definition of the syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Centromedian-Parafascicular Complex Deep Brain Stimulation for Tourette Syndrome: A Retrospective Study.Mayo Clinic proceedings · 2016Article
- Deep Brain Stimulation for Tourette's Syndrome: The Case for Targeting the Thalamic Centromedian-Parafascicular Complex.Frontiers in neurology · 2016Review
- Mechanisms of deep brain stimulation.Journal of neurophysiology · 2016Review
- The International Deep Brain Stimulation Registry and Database for Gilles de la Tourette Syndrome: How Does It Work?Frontiers in neuroscience · 2016Article
- Abnormal neuronal activity in Tourette syndrome and its modulation using deep brain stimulation.Journal of neurophysiology · 2015Review
- Deep Brain Stimulation in Tourette's Syndrome.Frontiers in neurology · 2015Review
- Uncommon applications of deep brain stimulation in hyperkinetic movement disorders.Tremor and other hyperkinetic movements (New York, N.Y.) · 2015Review
- Deep brain stimulation of the antero-medial globus pallidus interna for Tourette syndrome.PloS one · 2014Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeep brain stimulation (DBS) remains an experimental but promising treatment for patients with severe refractory Gilles de la Tourette syndrome (TS). Controversial issues include the selection of patients (age and clinical presentation), the choice of brain targets to obtain optimal patient-specific outcomes, and the risk of surgery- and stimulation-related serious adverse events.
methodsThis report describes our open-label experience with eight patients with severe refractory malignant TS treated with DBS. The electrodes were placed in the midline thalamic nuclei or globus pallidus, pars internus, or both. Tics were clinically assessed in all patients pre- and postoperatively using the Modified Rush Video Protocol and the Yale Global Tic Severity Scale (YGTSS).
resultsAlthough three patients had marked postoperative improvement in their tics (>50% improvement on the YGTSS), the majority did not reach this level of clinical improvement. Two patients had to have their DBS leads removed (one because of postoperative infection and another because of lack of benefit). DISCUSSION: Our clinical experience supports the urgent need for more data and refinements in interventions and outcome measurements for severe, malignant, and medication-refractory TS. Because TS is not an etiologically homogenous clinical entity, the inclusion criteria for DBS patients and the choice of brain targets will require more refinement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.