ArticleRevista brasileira de hematologia e hemoterapia2013
Glomerular filtration rate is altered in children with sickle cell disease: a comparison between Hb SS and Hb SC.
Article in Revista brasileira de hematologia e hemoterapia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Pharmacokinetics of Antimicrobials in Children with Emphasis on Challenges Faced by Low and Middle Income Countries, a Clinical Review.Antibiotics (Basel, Switzerland) · 2022Review
- Sickle cell disease up-regulates vasopressin, aquaporin 2, urea transporter A1, Na-K-Cl cotransporter 2, and epithelial Na channels in the mouse kidney medulla despite compromising urinary concentration ability.Physiological reports · 2019Article
- Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association withDisease markers · 2019Article
- Dose Selection Based on Modeling and Simulation for Rivipansel in Pediatric Patients Aged 6 to 11 Years With Sickle Cell Disease.CPT: pharmacometrics & systems pharmacology · 2017Article
- Congolese children with sickle cell trait may exhibit glomerular hyperfiltration: A case control study.Journal of clinical laboratory analysis · 2017Article
- Comments on renal abnormalities of sickle cell disease.Revista brasileira de hematologia e hemoterapia · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRenal failure is common among older patients with sickle cell disease; this is preceded by subclinical glomerular hyperfiltration. Data about renal function of adults with sickle cell disease have been reported, but data on children is scarce, especially when comparing heterozygotic and homozygotic patients.
objectiveThe goal of this study was to investigate the glomerular filtration rate of heterozygotic and homozygotic children with sickle cell disease.
methodsThe glomerular filtration rate of 11 children with sickle cell disease [7 homozygotic (SS) and 4 heterozygotic (SC)] with a mean age of 11 years (standard deviation: ± 5 years) was evaluated using standard laboratory techniques. Results are presented as descriptive analysis.
resultsOur results suggest that glomerular hyperfiltration is present in children with sickle cell disease; this is more evident in homozygotic than heterozygotic children.
conclusionThere is evidence of a need to monitor the renal function of children with sickle cell disease when special attention should be paid to homozygotic patients.
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