ReviewClinical interventions in aging2013
What is an appropriate blood pressure goal for the elderly: review of recent studies and practical recommendations.
Review in Clinical interventions in aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05690997 (Effect of Intensive Blood Pressure Control on Cerebral Blood Flow and Cognition in Ischaemic Stroke Patients With Severe Cerebral Small Vessel Disease), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Intensive Blood Pressure Control on Cerebral Blood Flow and Cognition in Ischaemic Stroke Patients With Severe Cerebral Small Vessel Disease
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Effect of cocoa on blood pressure.The Cochrane database of systematic reviews · 2017Pooled it
- Intensive BP Control and Cognitive Function: A Randomized Clinical Trial.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Effect of Standard vs Intensive Blood Pressure Control on Cerebral Blood Flow in Small Vessel Disease: The PRESERVE Randomized Clinical Trial.JAMA neurology · 2018Trial
- Survival as a source of confounding, selection bias, and effect modification.International journal of epidemiology · 2026Article
- Article
- Risks and management of hypertension in cancer patients undergoing targeted therapy: a review.Clinical hypertension · 2022Review
- Higher Burden of Cerebral Small Vascular Disease Predicts Major Adverse Cardiac and Cerebrovascular Events and Is Related to Abnormal Blood Pressure Variability Pattern in Hypertension Patients.Frontiers in aging neuroscience · 2022Article
- Clinical Impact of Worsening Renal Function in Elderly Patients with Acute Decompensated Heart Failure.International journal of heart failure · 2021Article
- Use of advanced statistical techniques to predict all-cause mortality in the Systolic Blood Pressure Intervention Trial.International Journal of Cardiology. Hypertension · 2020Article
- High positive end expiratory pressure levels affect hemodynamics in elderly patients with hypertension admitted to the intensive care unit: a prospective cohort study.BMC pulmonary medicine · 2019Article
- Cardiovascular function and structure are preserved despite induced ablation of BMP1-related proteinases.Cellular and molecular bioengineering · 2018Article
- Hypotension and a positive fluid balance are associated with delirium in patients with shock.PloS one · 2018Article
- A novel healthy blood pressure phenotype in the Long Life Family Study.Journal of hypertension · 2018Article
- The influence of quality of life on the level of adherence to therapeutic recommendations among elderly hypertensive patients.Patient preference and adherence · 2018Article
- Evidence to Maintain the Systolic Blood Pressure Treatment Threshold at 140 mm Hg for Stroke Prevention: The Northern Manhattan Study.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Ratio between carotid artery stiffness and blood flow - a new ultrasound index of ischemic leukoaraiosis.Clinical interventions in aging · 2016Article
- Recognition and Management of Hypertension in Older Persons: Focus on African Americans.Journal of the American Geriatrics Society · 2015Review
- Hypertension criterion for stroke prevention--to strengthen the principle of individualization in guidelines.Journal of clinical hypertension (Greenwich, Conn.) · 2015Review
- Potential underdiagnosis of osteoporosis in repeated vertebral augmentation for new vertebral compression fractures.Clinical interventions in aging · 2015Article
- The expression and functional evidence for voltage-dependent potassium channel Kv1.3 in lymphocytes during aging in spontaneously hypertensive rats.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hypertension is common in the elderly, and isolated systolic hypertension is responsible for the majority of hypertension in this population. Hypertension in the elderly can be attributed to numerous structural and functional changes to the vasculature that develop with advancing age. Increased systolic blood pressure is associated with adverse outcomes, including stroke, cardiovascular disease, and death. Some studies demonstrate an inverse relationship between cardiovascular outcomes and diastolic blood pressure whereas other studies show a J-shaped or U-shaped association between blood pressure and outcomes. The complex J-shaped association coupled with the unique characteristics of elderly patients have led to much debate and confusion regarding the treatment of hypertension in this population. Clinical trials indicate a benefit to therapy in older adults, and there appears to be no age threshold above which antihypertensive therapy should be withheld. Treatment of hypertension in elderly patients is further complicated by increased susceptibility to brain hypoperfusion with orthostatic hypotension as well as the risk of drug-drug interactions. We recommend a systolic blood pressure goal of <140 mmHg in patients less than 80 years of age and a systolic blood pressure goal of 140-150 mmHg in patients 80 years of age or older. Reduction of blood pressure is probably more important than the specific agent used and initiation of drug therapy with an angiotensin converting enzyme inhibitor, angiotensin receptor blocker, calcium channel blocker, or diuretic are all reasonable options, and the decision should be individualized based on underlying comorbidities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.