ArticleEuropean heart journal2014
Computed tomography angiography and perfusion to assess coronary artery stenosis causing perfusion defects by single photon emission computed tomography: the CORE320 study.
Article in European heart journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 163 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implementing Myocardial Computed Tomographic Perfusion in a Community Hospital Setting
The Safety, Feasibility and Accuracy of Dynamic Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease
Ultra-High Resolution CT vs. Conventional Angiography for Detecting Hemodynamically Significant Coronary Artery Disease - The Core-PRECISION MULTI-CENTER STUDY
Who cites it
163 citing papers in PubMed, 1 synthesis or guideline pooled it, 432 citations in OpenAlex.
- SCCT 2021 Expert Consensus Document on Coronary Computed Tomographic Angiography: A Report of the Society of Cardiovascular Computed Tomography.Journal of cardiovascular computed tomographyGuideline
- Myocardial CT perfusion imaging for the detection of obstructive coronary artery disease: multisegment reconstruction does not improve diagnostic performance.European radiology experimental · 2022Trial
- Diagnostic yield and accuracy of coronary CT angiography after abnormal nuclear myocardial perfusion imaging.Scientific reports · 2018Trial
- Trial
- Trial
- Accuracy of Computed Tomographic Angiography and Single-Photon Emission Computed Tomography-Acquired Myocardial Perfusion Imaging for the Diagnosis of Coronary Artery Disease.Circulation. Cardiovascular imaging · 2015Trial
- Coronary Computed Tomography Angiography Versus Radionuclide Myocardial Perfusion Imaging in Patients With Chest Pain Admitted to Telemetry: A Randomized Trial.Annals of internal medicine · 2015Trial
- Patient satisfaction with coronary CT angiography, myocardial CT perfusion, myocardial perfusion MRI, SPECT myocardial perfusion imaging and conventional coronary angiography.European radiology · 2015Trial
- Transmural myocardial perfusion gradients in relation to coronary artery stenoses severity assessed by cardiac multidetector computed tomography.The international journal of cardiovascular imaging · 2015Trial
- Trial
- Combined coronary angiography and myocardial perfusion by computed tomography in the identification of flow-limiting stenosis - The CORE320 study: An integrated analysis of CT coronary angiography and myocardial perfusion.Journal of cardiovascular computed tomographyTrial
- Platform-specific impact of CT attenuation correction on CZT myocardial perfusion SPECT: per-vessel detection of obstructive coronary artery disease.The international journal of cardiovascular imaging · 2026Article
- A Clinical Impact Study of Myocardial Perfusion Imaging Comparing Three Different Cardiac Software Packages at 1-Year Follow-Up.World journal of nuclear medicine · 2026Article
- CAD-RADS: A Standardized Reporting System for Coronary CT Angiography.Journal of the Korean Society of Radiology · 2026Review
- Cost-effective integration of dynamic myocardial CT perfusion in the assessment of symptomatic coronary artery disease.European radiology · 2026Article
- Prognostic significance of cold pressor test myocardial perfusion imaging in patients with ischemia and nonobstructive coronary arteries.Quantitative imaging in medicine and surgery · 2025Article
- Acute Left Anterior Descending Occlusion Myocardial Infarction Incidentally Found on Surveillance Computed Tomography.JACC. Case reports · 2025Article
- Relationship between microvascular status and diagnostic performance of stress dynamic CT perfusion imaging.European radiology · 2025Article
- The metabolic score for insulin resistance index is associated with myocardial ischemia, with non-alcoholic fatty liver disease serving as an important bridge.Frontiers in endocrinology · 2025Article
- How to perform and evaluate a myocardial perfusion imaging by computed tomography.European heart journal. Imaging methods and practice · 2025Review
103 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 18 institutions in 8 countries.
Funding
Abstract
aimsTo evaluate the diagnostic power of integrating the results of computed tomography angiography (CTA) and CT myocardial perfusion (CTP) to identify coronary artery disease (CAD) defined as a flow limiting coronary artery stenosis causing a perfusion defect by single photon emission computed tomography (SPECT). METHODS AND
resultsWe conducted a multicentre study to evaluate the accuracy of integrated CTA-CTP for the identification of patients with flow-limiting CAD defined by ≥50% stenosis by invasive coronary angiography (ICA) with a corresponding perfusion deficit on stress single photon emission computed tomography (SPECT/MPI). Sixteen centres enroled 381 patients who underwent combined CTA-CTP and SPECT/MPI prior to conventional coronary angiography. All four image modalities were analysed in blinded independent core laboratories. The prevalence of obstructive CAD defined by combined ICA-SPECT/MPI and ICA alone was 38 and 59%, respectively. The patient-based diagnostic accuracy defined by the area under the receiver operating characteristic curve (AUC) of integrated CTA-CTP for detecting or excluding flow-limiting CAD was 0.87 [95% confidence interval (CI): 0.84-0.91]. In patients without prior myocardial infarction, the AUC was 0.90 (95% CI: 0.87-0.94) and in patients without prior CAD the AUC for combined CTA-CTP was 0.93 (95% CI: 0.89-0.97). For the combination of a CTA stenosis ≥50% stenosis and a CTP perfusion deficit, the sensitivity, specificity, positive predictive, and negative predicative values (95% CI) were 80% (72-86), 74% (68-80), 65% (58-72), and 86% (80-90), respectively. For flow-limiting disease defined by ICA-SPECT/MPI, the accuracy of CTA was significantly increased by the addition of CTP at both the patient and vessel levels.
conclusionsThe combination of CTA and perfusion correctly identifies patients with flow limiting CAD defined as ≥50 stenosis by ICA causing a perfusion defect by SPECT/MPI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.