ArticleEndocrine2014
Roles of thyroid hormones in follicular development in the ovary of neonatal and immature rats.
Article in Endocrine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Mendelian randomization study of thyroid function and anti-Müllerian hormone levels.Frontiers in endocrinology · 2023Pooled it
- How to Differentiate General Toxicity-Related Endocrine Effects from Endocrine Disruption: Systematic Review of Carbon Disulfide Data.International journal of molecular sciences · 2022Pooled it
- From Follicle Development to Fertilization: How PCBs and PFAS May Shape Female Reproductive Health.Toxics · 2026Review
- Integrated multi-population selection-signature scans identify putative functional genes influencing litter size in jishen black pigs.BMC genomics · 2026Article
- Resolved hyperthyroidism before IVF is not associated with improved cumulative live birth rates: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- The protective role of vitamin E against the effects of hyperthyroidism on the rat pituitary-ovary axis.Histochemistry and cell biology · 2025Article
- Role of TInternational journal of molecular sciences · 2025Article
- DNA Methylation Patterns and Transcriptomic Data Were Integrated to Investigate Candidate Genes Influencing Reproductive Traits in Ovarian Tissue from Sichuan White Geese.International journal of molecular sciences · 2025Article
- Metabolomics of follicular fluid reveals the impact of heat stress on oocyte pick-up and in vitro embryo production efficiency in dairy cows.Journal of animal science · 2025Article
- Per- and polyfluoroalkyl substances exposure is associated with polycystic ovary syndrome risk among women attending a fertility clinic.The Science of the total environment · 2024Article
- Associations between a normal-range free thyroxine concentration and ovarian reserve in infertile women undergoing treatment via assisted reproductive technology.Reproductive biology and endocrinology : RB&E · 2024Article
- Autoimmune thyroid disease and ovarian hypofunction: a review of literature.Journal of ovarian research · 2024Review
- Review
- Repercussion of thyroid dysfunctions in thyroidology on the reproductive system: Conditio sine qua non?Revista da Associacao Medica Brasileira (1992) · 2022Article
- Article
- Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary.Human reproduction update · 2020Article
- Thyroid Hormones and Functional Ovarian Reserve: Systemic vs. Peripheral Dysfunctions.Journal of clinical medicine · 2020Review
- Thyroid hormones T3 and T4 regulate human luteinized granulosa cells, counteracting apoptosis and promoting cell survival.Journal of endocrinological investigation · 2020Article
- Nervous mechanisms of restraint water-immersion stress-induced gastric mucosal lesion.World journal of gastroenterology · 2020Review
- Serum and follicular fluid thyroid hormone levels and assisted reproductive technology outcomes.Reproductive biology and endocrinology : RB&E · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormones (TH) play a critical role in ovarian follicular development, maturation and the maintenance of various endocrine functions. However, whether TH can affect ovarian follicular development in neonatal and immature rats remains unclear. Therefore, the aim of the present study was to elucidate the effect of TH on ovarian follicular development in neonatal and immature rats. Thirty female post-lactation mothers of Sprague-Dawley rat pups were randomly divided into three groups: control, hyperthyroid (hyper), and hypothyroid (hypo). On postnatal days (PND) 10 and 21, body weights, serum hormones, ovarian histologic changes, and immunohistochemistry of thyroid hormone receptor alpha 1 (TRα1) and nitric oxide synthase types (NOS), and NOS activities, were determined. The data showed that body weights significantly decreased in both hyper and hypo groups compared with the control group (P < 0.05). In addition, the hyper group had increased serum concentrations of T3, T4, and E2; whereas the hypo group manifested reduced serum concentrations of T3, T4, and E2 on PND 10 and 21. The hyper and hypo groups showed significantly reduced total number of primordial, primary and secondary follicles on PND 10 and 21 compared with the control group (P < 0.05). Similarly, antral follicle numbers in the hyper and hypo groups were significantly decreased on PND 21 compared with the control group (P < 0.05). Immunostaining indicated that TRα1 and NOS were expressed in ovarian surface epithelium and oocytes of growing and antral follicles, with strong staining of the granulosa and theca cells of follicles. NOS activities were significantly augmented in the hyper, but diminished in the hypo groups on PND 10 and 21. In summary, our findings suggest that TH play important roles in ovarian functions and in the regulation of NOS activity. Our results also indicate that a relationship exists between the TH and NO signaling pathways during the process of ovarian follicular development in neonatal and immature rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.