ReviewDepression and anxiety2014
From the neurobiology of extinction to improved clinical treatments.
Review in Depression and anxiety, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- A systematic review of the neural bases of psychotherapy for anxiety and related disorders.Dialogues in clinical neuroscience · 2015Pooled it
- Within-patient association between emotion regulation and outcome in prolonged exposure for posttraumatic stress disorder.Journal of consulting and clinical psychology · 2024Trial
- Trauma cognitions are related to symptoms up to 10 years after cognitive behavioral treatment for posttraumatic stress disorder.Psychological trauma : theory, research, practice and policy · 2017Trial
- Article
- RESET post-traumatic stress disorder: clinical protocol integrating reconsolidation, exposure, short-term emotional transformation.European journal of psychotraumatology · 2025Article
- Transcriptomic Architecture of Weak Versus Strong Contextual Fear Extinction Learning Uncovers Extinction-Suppressive Role of TIA1.Biological psychiatry global open science · 2025Article
- Distinct subpopulations of parvalbumin neurons participating in divergent prefrontal functions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Counterconditioning reduces contextual renewal in a novel context but not in the acquisition context.Neurobiology of learning and memory · 2023Article
- Expanding the canon: An inclusive neurobiology of thalamic and subthalamic fear circuits.Neuropharmacology · 2023Review
- An epigenetic mechanism for over-consolidation of fear memories.Molecular psychiatry · 2022Article
- Putting the "mental" back in "mental disorders": a perspective from research on fear and anxiety.Molecular psychiatry · 2022Review
- Blockade of D-serine signaling and adult hippocampal neurogenesis attenuates remote contextual fear memory following multiple memory retrievals in male mice.Frontiers in neuroscience · 2022Article
- Environmental certainty influences the neural systems regulating responses to threat and stress.Neuroscience and biobehavioral reviews · 2021Review
- Elevated activity in the dorsal dentate gyrus reduces expression of fear memory after fear extinction training.Journal of psychiatry & neuroscience : JPN · 2021Article
- Efficacy Evaluation of Neurofeedback-Based Anxiety Relief.Frontiers in neuroscience · 2021Article
- Plasticity of GluN1 at Ventral Hippocampal Synapses in the Infralimbic Cortex.Frontiers in synaptic neuroscience · 2021Article
- Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning.Nature communications · 2020Article
- Effects of ∆BMC psychiatry · 2020Review
- Odor modulates the temporal dynamics of fear memory consolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning.Neuroscience and biobehavioral reviews · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The neural circuitry underlying the fear response is extremely well conserved across mammalian species, which has allowed for the rapid translation of research findings in rodent models of fear to therapeutic interventions in human populations. Many aspects of exposure-based psychotherapy treatments in humans, which are widely used in the treatment of PTSD, panic disorder, phobias, and other anxiety disorders, are closely paralleled by extinction training in rodent fear conditioning models. Here, we discuss how the neural circuitry of fear learning and extinction in rodent animal models may be used to understand the underlying neural circuitry of fear-related disorders, such as PTSD in humans. We examine the factors that contribute to the pathology and development of PTSD. Next, we will review how fear is measured in animal models using classical Pavlovian fear conditioning paradigms, as well as brain regions such as the amygdala, which are involved in the fear response across species. Finally, we highlight the following three systems involved in the extinction of fear, all of which represent promising avenues for therapeutic interventions in the clinic: (1) the role of the glutamatergic N-methyl-d-aspartate (NMDA) receptor, (2) the role of the brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB) induced signaling pathway, and (3) the role of the renin-angiotensin system. The modulation of pathways underlying fear learning and extinction, such as the ones presented in this review, in combination with extinction-based exposure therapy, represents promising avenues for therapeutic intervention in the treatment of human fear related disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.