ArticleDevelopmental neurobiology2014
Axonal cap-dependent translation regulates presynaptic p35.
Article in Developmental neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Axonal mRNA localization and translation: local events with broad roles.Cellular and molecular life sciences : CMLS · 2021Review
- A Yeast System for Discovering Optogenetic Inhibitors of Eukaryotic Translation Initiation.ACS synthetic biology · 2019Article
- Intra-axonal protein synthesis in development and beyond.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2016Review
- Regulation of neuronal gene expression by local axonal translation.Current genetic medicine reports · 2016Article
- Cyfip1 Regulates Presynaptic Activity during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Sumoylation of p35 modulates p35/cyclin-dependent kinase (Cdk) 5 complex activity.Neuromolecular medicine · 2015Article
- Advances in imaging ultrastructure yield new insights into presynaptic biology.Frontiers in cellular neuroscience · 2015Review
- Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits.The Journal of comparative neurology · 2015Article
- Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Axonal growth cones synthesize proteins during development and in response to injury in adult animals. Proteins locally translated in axons are used to generate appropriate responses to guidance cues, contribute to axon growth, and can serve as retrograde messengers. In addition to growth cones, mRNAs and translational machinery are also found along the lengths of axons where synapses form en passant, but contributions of intra-axonal translation to developing synapses are poorly understood. Here, we engineered a subcellular-targeting translational repressor to inhibit mRNA translation in axons, and we used this strategy to investigate presynaptic contributions of cap-dependent protein translation to developing CNS synapses. Our data show that intra-axonal mRNA translation restrains synaptic vesicle recycling pool size and that one target of this regulation is p35, a Cdk5 activating protein. Cdk5/p35 signaling regulates the size of vesicle recycling pools, p35 levels diminish when cap-dependent translation is repressed, and restoring p35 levels rescues vesicle recycling pools from the effects of spatially targeted translation repression. Together our findings show that intra-axonal synthesis of p35 is required for normal vesicle recycling in developing neurons, and that targeted translational repression provides a novel strategy to investigate extrasomal protein synthesis in neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.