ArticleSleep & breathing = Schlaf & Atmung2014
The lateral habenular nucleus mediates signal transduction from the insular cortex in OSA rats.
Article in Sleep & breathing = Schlaf & Atmung, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Posterior insular cortex hyperactivation drives vestibular migraine and comorbid anxiety.The journal of headache and pain · 2026Article
- Mood Disorders are Correlated with Autonomic Nervous Function in Chronic Insomnia Patients with OSA.Nature and science of sleep · 2023Article
- In light of breathing: environmental light is an important modulator of breathing with clinical implications.Frontiers in neuroscience · 2023Article
- Aberrant Resting-State Functional Brain Connectivity of Insular Subregions in Obstructive Sleep Apnea.Frontiers in neuroscience · 2021Article
- Habenula lesions improve glucose metabolism in rats with type 2 diabetes by increasing insulin sensitivity and inhibiting gluconeogenesis.BMJ open diabetes research & care · 2020Article
- New insights on the role of the insular cortex and habenula in OSA.Sleep & breathing = Schlaf & Atmung · 2015Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe insular cortex (Ic) and habenular nuclei (Hb) of the limbic system are associated with human and animal dyspnea by regulating 5-hydroxytryptamine (5-HT) release in the raphe nuclei (RN). However, the Hb are composed of the medial habenular nucleus (MHb) and the lateral habenular nucleus (LHb). Therefore, it is still unclear whether the Ic signal is conducted through the MHb or LHb. This study aimed to investigate the role of the Hb and Ic in obstructive sleep apnea syndrome (OSA) and the functional relationship between these two structures.
methodsWe monitored multiple indicators, including the respiration movement curve, neuronal activity in the MHb and LHb, and arterial blood gas, when stimulating the anterior Ic of Wistar rats. We compared the results with the control group (stimulating the surrounding cortex).
resultsElectrical stimulation of the Ic in the rat brain caused respiratory disturbances, apnea, reduced blood pH, and aggravated base deficit (more negative base excess value) compared to control animals (p < 0.05). It also reduced the spontaneous firing of the MHb neurons but increased that of the LHb neurons. Electrical stimulation of the Ic induces apnea in rats in a similar manner to human OSA. The Ic and the Hb are functionally linked. Stimulation of the Ic inhibits the MHb, but activates the LHb. It induces OSA-like symptoms by enhancing LHb-mediated inhibition of the RN.
conclusionsThis study illustrates the mechanism by which an animal model of OSA is created by stimulating the Ic and promotes understanding of OSA pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.