ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Pooled it
- Association between PLCE1 rs2274223 A > G polymorphism and cancer risk: proof from a meta-analysis.Scientific reports · 2015Pooled it
- Article
- Functional Annotation and Gene Set Analysis of Gastric Cancer Risk Loci in a Korean Population.Cancer research and treatment · 2024Article
- Lifestyles, genetics, and future perspectives on gastric cancer in east Asian populations.Journal of human genetics · 2021Review
- Polymorphism ofFrontiers in oncology · 2021Article
- Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran.BMC medical genetics · 2020Article
- Role ofInternational journal of clinical and experimental pathology · 2020Article
- Genome-Wide Association of Genetic Variation in the PSCA Gene with Gastric Cancer Susceptibility in a Korean Population.Cancer research and treatment · 2019Article
- Association of MUC1 rs4072037 Functional Polymorphism and Cancer Risk: Evidence from 12551 Cases and 13436 Controls.Journal of Cancer · 2018Article
- Single Nucleotide Polymorphisms inFrontiers in oncology · 2018Article
- Functional polymorphisms inOncotarget · 2017Article
- PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy.Oncotarget · 2017Article
- The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression.Journal of Cancer · 2017Review
- AURKA induces EMT by regulating histone modification through Wnt/β-catenin and PI3K/Akt signaling pathway in gastric cancer.Oncotarget · 2016Article
- Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.Oncotarget · 2016Article
- Mucin 1 gene (MUC1) and gastric-cancer susceptibility.International journal of molecular sciences · 2014Article
- Ethnic differences in gastric cancer genetic susceptibility: allele flips of interleukin gene.World journal of gastroenterology · 2014Review
- MUC1 gene polymorphism rs4072037 and susceptibility to gastric cancer: a meta-analysis.SpringerPlus · 2014Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic variants at 1q22 and 10q23 were identified as genetic markers of both gastric cancer and esophageal squamous cell carcinoma susceptibility by two genome-wide association studies. The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population. We conducted a large-scale case-control study of 3,245 patients with gastric cancer and 1,700 controls. The allele frequencies of rs4072037G and rs2274223G were 11.2 and 25.5% among patients with gastric cancer, compared with 12.8 and 26.4%, respectively, among controls. We found that the rs4072037 AG genotype was significantly associated with a reduced risk of gastric cancer [odds ratios (OR) = 0.78; 95% confidence interval (CI) = 0.67-0.91 for AG vs AA]. Compared with the rs2274223 AA genotype, we found a significant association between the rs2274223 AG genotype and a weakly reduced risk of gastric cancer (OR = 0.87; 95% CI = 0.76-0.99 for AG vs AA). Our data suggest that genetic variants at 1q22 and 10q23 play a role in gastric carcinogenesis.
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