ReviewJournal of molecular neuroscience : MN2014
Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease.
Review in Journal of molecular neuroscience : MN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Butyrylcholinesterase K variant and Alzheimer's disease risk: a meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Effect of transcutaneous auricular vagus nerve stimulation on delayed neurocognitive recovery in elderly patients.Aging clinical and experimental research · 2022Trial
- Low serum pseudocholinesterase levels are associated with mortality in patients with hepatocellular carcinoma.Hepatology communications · 2026Article
- Maternal prenatal stress induces sex-dependent changes in tRNA fragment families and cholinergic pathways in newborns.Molecular psychiatry · 2025Article
- New views on physiological functions and regulation of butyrylcholinesterase and potential therapeutic interventions.Frontiers in molecular biosciences · 2025Review
- Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery.Frontiers in cellular neuroscience · 2024Review
- Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis.Biomedicines · 2023Article
- Increased Enzymatic Activity of Acetylcholinesterase Indicates the Severity of the Sterile Inflammation and Predicts Patient Outcome following Traumatic Injury.Biomolecules · 2023Article
- Acetylcholinesterase, pro-inflammatory cytokines, and association of ACHE SNP rs 17228602 with male infertility.PloS one · 2023Article
- Critically Ill COVID-19 Patients Show Reduced Point of Care-Measured Butyrylcholinesterase Activity-A Prospective, Monocentric Observational Study.Diagnostics (Basel, Switzerland) · 2022Article
- Early Biomarkers and Intervention Programs for the Infant Exposed to Prenatal Stress.Current neuropharmacology · 2022Article
- Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients.BMC medical genomics · 2021Observational
- Hypertension is associated with increased post-exercise albuminuria, which may be attenuated by an active lifestyle.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Butyrylcholinesterase-a potential plasma biomarker in manganese-induced neurobehavioral changes.Environmental science and pollution research international · 2019Article
- Obesity-related acetylcholinesterase elevation is reversed following laparoscopic sleeve gastrectomy.International journal of obesity (2005) · 2019Article
- Septic patients presenting with apparently normal C-reactive protein: A point of caution for the ER physician.Medicine · 2019Observational
- Total serum cholinesterase activity predicts hemodynamic changes during exercise and associates with cardiac troponin detection in a sex-dependent manner.Molecular medicine (Cambridge, Mass.) · 2018Article
- Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients.Mediators of inflammation · 2018Article
- Cholinesterase-like organocatalysis by imidazole and imidazole-bearing molecules.Scientific reports · 2017Article
- Serum Butyrylcholinesterase Activity: A Biomarker for Parkinson's Disease and Related Dementia.BioMed research international · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence suggests parasympathetic dysfunction and elevated inflammation as underlying processes in multiple peripheral and neurological diseases. Acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (AChE and BChE, respectively), which are also expressed in the serum. Here, we consider the potential value of both enzymes as possible biomarkers in diseases associated with parasympathetic malfunctioning. We cover the modulations of cholinesterase activities in inflammation-related events as well as by cholinesterase-targeted microRNAs. We further discuss epigenetic control over cholinesterase gene expression and the impact of single-nucleotide polymorphisms on the corresponding physiological and pathological processes. In particular, we focus on measurements of circulation cholinesterases as a readily quantifiable readout for changes in the sympathetic/parasympathetic balance and the implications of changes in this readout in health and disease. Taken together, this cumulative know-how calls for expanding the use of cholinesterase activity measurements for both basic research and as a clinical assessment tool.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.