Evidence map›Paper›PMID 24253763›Full record

ArticleEuropean journal of clinical nutrition2014

PKU patients on a relaxed diet may be at risk for micronutrient deficiencies.

C Rohde, A von Teeffelen-Heithoff, A G Thiele, M Arelin, U Mütze, C Kiener, J Gerloff, C Baerwald, S Schultz, C Heller and 3 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Current state of the treatment landscape of phenylketonuria.Orphanet journal of rare diseases · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

C RohdeHospital for Children and Adolescents, Centre of Paediatric Research (CPL), Department of Women and Child Health, University Hospitals, University of Leipzig, Leipzig, Germany.
A von Teeffelen-HeithoffDepartment of Pediatrics, University Hospital, University of Münster, Münster, Germany.
A G ThieleHospital for Children and Adolescents, Centre of Paediatric Research (CPL), Department of Women and Child Health, University Hospitals, University of Leipzig, Leipzig, Germany.
M ArelinHospital for Children and Adolescents, Centre of Paediatric Research (CPL), Department of Women and Child Health, University Hospitals, University of Leipzig, Leipzig, Germany.
U MützeHospital for Children and Adolescents, Centre of Paediatric Research (CPL), Department of Women and Child Health, University Hospitals, University of Leipzig, Leipzig, Germany.
C KienerNutricia GmbH, Heilbronn, Germany.
J GerloffNutricia GmbH, Heilbronn, Germany.
C BaerwaldDepartment of Internal Medicine, University Hospitals, University of Leipzig, Leipzig, Germany.
S SchultzCenter for Obstetrics and Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg-Eppendorf, Germany.
C HellerDepartment of Paediatrics and Adolescent Medicine, University Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
A S MüllerInstitute of Agricultural and Nutritional Sciences, Martin-Luther-University, Halle-Wittenberg, Germany.
W KiessHospital for Children and Adolescents, Centre of Paediatric Research (CPL), Department of Women and Child Health, University Hospitals, University of Leipzig, Leipzig, Germany.
S BebloHospital for Children and Adolescents, Centre of Paediatric Research (CPL), Department of Women and Child Health, University Hospitals, University of Leipzig, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate micronutrient supply in phenylketonuria (PKU) patients on a relaxed diet. SUBJECTS/

methodsSixty-seven patients (6-45 years) with a phenylalanine tolerance ≥ 600 mg/day were included in the study. From a 3-day diet record, protein supply as well as consumption of essential amino acids and several micronutrients were assessed and compared with the current recommendations and data for the healthy population.

resultsProtein supply and consumption of all essential amino acids were sufficient in all patients. Supply of micronutrients depended on dietary regime. Patients with a total protein supply of 120% or more of the recommended amount and at least 0.5 g protein per kg body weight from amino-acid mixture (AAM) were sufficiently supplied with all investigated micronutrients. All patients without AAM supplement showed severe micronutrient deficiencies in their diet records.

conclusionPKU patients under a relaxed diet are at risk of an insufficient nutrient supply, if they have first no substitution with AAM, second a protein supply less than 0.5 g per kg body weight from AAM or third a total protein supply less than 120% of the recommendations. Therefore, close monitoring, specific dietary counseling and potential supplementation is mandatory to prevent micronutrient deficiencies in PKU patients.

Indexed as

DietDietary SupplementsAdolescentAdultAmino AcidsBody WeightChildCross-Sectional StudiesDietary ProteinsDiet RecordsHumansMicronutrientsMiddle AgedPhenylalaninePhenylketonuriasYoung AdultAmino AcidsDietary ProteinsMicronutrientsPhenylalanine

Identifiers

PMID24253763

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.