Trial reportClinical and experimental nephrology2014
Cystatin C-based equation for estimating glomerular filtration rate in Japanese children and adolescents.
Trial report in Clinical and experimental nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Comparison of inulin clearance with 2-h creatinine clearance in Japanese pediatric patients with renal disease: open-label phase 3 study of inulin.Clinical and experimental nephrology · 2022Trial
- Protocol for the nationwide registry of patients with polycystic kidney disease: japanese national registry of PKD (JRP).Clinical and experimental nephrology · 2024Article
- Assessment of the renal function of patients with anorexia nervosa.BioPsychoSocial medicine · 2024Article
- Plasma D-asparagine and the D/L-serine ratio reflect chronic kidney diseases in children regardless of physique.Amino acids · 2024Article
- Association of albuminuria with kidney function and hemodynamic disturbance in pre-school children who undergo congenital heart disease surgery.Pediatric nephrology (Berlin, Germany) · 2024Article
- Cystatin C as a GFR Estimation Marker in Acute and Chronic Illness: A Systematic Review.Kidney medicine · 2023Article
- Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities.JMA journal · 2023Article
- High serum cystatin C levels in juvenile myelomonocytic leukemia patients without abnormal kidney function.Pediatric nephrology (Berlin, Germany) · 2022Article
- Validation of the estimated glomerular filtration rate equation for Japanese children younger than 2 years.Clinical and experimental nephrology · 2022Article
- Reduction in urinary angiotensinogen levels and improvement of proteinuria by renin-angiotensin system blockade in pediatric chronic kidney disease patients with very low birth weight.Pediatric nephrology (Berlin, Germany) · 2020Article
- Enhanced angiotensinogen expression in neonates during kidney development.Clinical and experimental nephrology · 2019Article
- Combining GFR estimates from cystatin C and creatinine-what is the optimal mix?Pediatric nephrology (Berlin, Germany) · 2018Article
- Validation of estimated glomerular filtration rate equations for Japanese children.Clinical and experimental nephrology · 2018Article
- Influence of thyroid function on glomerular filtration rate and other estimates of kidney function in two pediatric patients.CEN case reports · 2018Article
- Assessment of Potential Renal Dysfunction in Patients with Congenital Heart Disease after Biventricular Repair.Korean circulation journal · 2018Article
- Creatinine-based estimated glomerular filtration rate for children younger than 2 years.Clinical and experimental nephrology · 2018Article
- Establishing the presence or absence of chronic kidney disease: Uses and limitations of formulas estimating the glomerular filtration rate.World journal of methodology · 2017Review
- Re-recognition of Age-dependent Reference Range for the Serum Creatinine Level in Teenagers - A Case of Slowly Progressive Tubulointerstitial Nephritis which Occurred in an Adolescent.Internal medicine (Tokyo, Japan) · 2017Article
- Longitudinal analysis of serum cystatin C for estimating the glomerular filtration rate in preterm infants.Pediatric nephrology (Berlin, Germany) · 2016Article
- Assessment of kidney function in children by enzymatic determination of 2- or 24-h creatinine clearance: comparison with inulin clearance.Clinical and experimental nephrology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRenal inulin clearance is the gold standard for evaluation of kidney function, but is compromised by problems of collecting urine samples in children, especially those <6 years or with a bladder dysfunction. Therefore, we should utilize the serum cystatin C (cysC)-based estimated glomerular filtration rate (eGFR) for measuring serum cysC. The purpose of the present study is to determine the applicability of the new serum cysC-based eGFR in Japanese children and adolescents, including infants with chronic kidney disease (CKD), for evaluation of renal function.
methodsInulin clearance and standardized serum cysC level determined by the colloidal gold immunoassay were measured in 135 pediatric CKD patients between the ages of 1 month and 18 years with no underlying disease that affects renal function except CKD, to determine serum cysC-based eGFR in Japanese children and adolescents.
resultsWe showed the inulin clearance by expression of 1/serum cysC in pediatric CKD patients, which resulted in the equation: inulin GFR (mL/min/1.73 m(2)) = 104.1 × 1/serum cysC (mg/L) - 7.80. We also validated the cysC-based eGFR formula for Japanese adults. eGFR values obtained with the adult formula significantly underestimated GFR by approximately 8 % in children with CKD.
conclusionWe determined the new cysC-based eGFR formula is useful for clinical screening of renal function in Japanese children and adolescents, including infants.
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