ArticleProceedings of the National Academy of Sciences of the United States of America1986
Clustered arrangement of keratin intermediate filament genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 51 citations in OpenAlex.
- Revisiting the significance of keratin expression in complex epithelia.Journal of cell science · 2022Article
- Article
- Expression of a wool intermediate filament keratin transgene in sheep fibre alters structure.Transgenic research · 1998Article
- The commercial and agricultural applications of animal transgenesis.Molecular biotechnology · 1995Review
- The genetic engineering of production traits in domestic animals.Experientia · 1991Review
- An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- Cyclic hair-loss and regrowth in transgenic mice overexpressing an intermediate filament gene.The EMBO journal · 1990Article
- Two type II keratin genes are localized on human chromosome 12.Human genetics · 1989Article
- Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells.Molecular and cellular biology · 1988Article
- Concerted gene duplications in the two keratin gene families.Journal of molecular evolution · 1988Article
- The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.The EMBO journal · 1987Article
- Differentially expressed bovine cytokeratin genes. Analysis of gene linkage and evolutionary conservation of 5'-upstream sequences.The EMBO journal · 1987Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here that component members of the keratin intermediate filament (IF) type I and type II gene families of sheep are closely linked but apparently the two families are not. Nine genes, accounting for up to half of the keratin IF gene repertoire, were mapped in four cosmid clones and the linkage between the genes ranged from several kilobases to 20 kilobases. In one cosmid, three tandem type I genes had the same transcriptional arrangement and were regularly spaced. In another cosmid, tandem genes encoding type II keratins were identified and, surprisingly, a solitary exon was discovered in the intergene region between the two type II genes. In a normal gene this exon encodes one of the most conserved amino acid regions of IF proteins, the C-terminal end of the alpha-helical core. Homologous C-terminal protein subdomains were encoded by two wool keratin type II genes and we suggest that this arrangement may also exist in the other wool keratin type II genes.
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